D-Ribose 1,5-diphosphate
D-Ribose 1,5-diphosphate (R15P) is a metabolic intermediate and enzyme substrate. Purified Tk-E2b2 converts D-Ribose 1,5-diphosphate into Ribulose-1,5-bisphosphate, with a specific activity of 32.3 μmol min-1 mg-1[1].
For research use only. We do not sell to patients.
- CAS No.: 14689-84-0
- Formula: C5H12O11P2
- Molecular Weight:310.09
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
D-Ribose 1,5-diphosphate can be efficiently catalyzed and isomerized to ribulose-1,5-bisphosphate by Tk-R15Pi, with a specific activity of 28.6 ± 1.1 μmol min-1 mg-1 and a reaction equilibrium constant of 16.3 ± 0.2. This equilibrium favors product formation[1].
D-Ribose 1,5-diphosphate is not utilized as a substrate by Tk-R15Pi, as reflected by the undetectable catalytic activity of this anomer (<0.1 μmol min-1 mg-1)[1].
D-Ribose 1,5-diphosphate can be converted into ribulose-1,5-bisphosphate by purified Thermococcus kodakaraensis Tk-E2b2, with a specific activity of 32.3 μmol min-1 mg-1[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 14689-84-0
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Appearance Solid
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Molecular Weight 310.09
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Formula C5H12O11P2
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Color White to off-white
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SMILES
O=P(O)(O)OC[C@H]1OC(OP(O)(O)=O)[C@H](O)[C@@H]1O
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Synonyms
R15P
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (282 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Nakamura A, et al. Dynamic, ligand-dependent conformational change triggers reaction of ribose-1,5-bisphosphate isomerase from Thermococcus kodakarensis KOD1. J Biol Chem. 2012;287(25):20784-20796. [Content Brief]
[2]. Sato T, et al. Archaeal type III RuBisCOs function in a pathway for AMP metabolism. Science. 2007;315(5814):1003-1006. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
D-Ribose 1,5-diphosphate Related Classifications
HY-114327 Related Classifications
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- D-Ribose 1,5-diphosphate
- 14689-84-0
- R15P
- Endogenous Metabolite
- Drug Intermediate
- Biochemical Assay Reagents
- ribose-1,5-bisphosphate isomerase
- α-anomer
- Thermococcus kodakaraensis
- 3-phosphoglycerate
- ribulose 1,5-bisphosphate
- β-anomer
- anaerobic archaea
- cis-phosphoenolate intermediate
- type III RuBisCO
- Thermococcus kodakarensis KOD1
- Inhibitor
- inhibitor
- inhibit