D-Ribose 1,5-diphosphate  (Synonyms: R15P)

D-Ribose 1,5-diphosphate (R15P) is a metabolic intermediate and enzyme substrate. Purified Tk-E2b2 converts D-Ribose 1,5-diphosphate into Ribulose-1,5-bisphosphate, with a specific activity of 32.3 μmol min^-1 mg^-1[1][2].

D-Ribose 1,5-diphosphate can be efficiently catalyzed and isomerized to ribulose-1,5-bisphosphate by Tk-R15Pi, with a specific activity of 28.6 ± 1.1 μmol min^-1 mg^-1 and a reaction equilibrium constant of 16.3 ± 0.2. This equilibrium favors product formation^[1].
D-Ribose 1,5-diphosphate is not utilized as a substrate by Tk-R15Pi, as reflected by the undetectable catalytic activity of this anomer (<0.1 μmol min^-1 mg^-1)^[1].
D-Ribose 1,5-diphosphate can be converted into ribulose-1,5-bisphosphate by purified Thermococcus kodakaraensis Tk-E2b2, with a specific activity of 32.3 μmol min^-1 mg^-1[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

310.09

C₅H₁₂O₁₁P₂

14689-84-0

Solid

White to off-white

O=P(O)(O)OC[C@H]1OC(OP(O)(O)=O)[C@H](O)[C@@H]1O

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Nakamura A, et al. Dynamic, ligand-dependent conformational change triggers reaction of ribose-1,5-bisphosphate isomerase from Thermococcus kodakarensis KOD1. J Biol Chem. 2012;287(25):20784-20796.  [Content Brief]

  [2]. Sato T, et al. Archaeal type III RuBisCOs function in a pathway for AMP metabolism. Science. 2007;315(5814):1003-1006.  [Content Brief]