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Talacotuzumab

(Synonyms: JNJ 56022473; CSL 362)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Talacotuzumab (JNJ 56022473; CSL 362) is an IgG1-type fully humanized, CD123-neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has KDs of 0.43 nM, 188 nM, 46 nM, 16.8 nM for CD123, CD32b/c, CD16-158F, CD16-158V, respectively. Talacotuzumab inhibits IL-3 binding to CD123, antagonizing IL-3 signaling in target cells. Talacotuzumab has mutated the Fc region to increase affinity for CD16 (FcγRIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab is highly effective in vivo reducing leukemic cell growth in acute myeloid leukemia (AML) xenograft mouse models.

For research use only. We do not sell to patients.

  • Purity: 98.82%
  • CAS No.: 1826831-79-1
  • Molecular Weight:147.42 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Talacotuzumab
  • Experimental Validation Results for Talacotuzumab
  • Experimental Validation Results for Talacotuzumab
  • Talacotuzumab Chemical Structure
    Talacotuzumab Chemical Structure
CAS No.: 1826831-79-1
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Talacotuzumab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized IL-3R alpha/CD123 Protein, Human can bind Talacotuzumab. The EC50 for this effect is 6.855 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5X106 THP-1 cells labeling Talacotuzumab (HY-P99395, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Talacotuzumab Chemical Structure
    1/16
  • Talacotuzumab
  • Immobilized IL-3R alpha/CD123 Protein, Human can bind Talacotuzumab. The EC50 for this effect is 6.855 ng/mL.
  • Flow cytometric analysis of 1.5X106 THP-1 cells labeling Talacotuzumab (HY-P99395, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).