2. Apoptosis
  3. Apoptosis
  4. Antiproliferative agent-32

Antiproliferative agent-32 (Compound 1c) inhibits the phosphorylation of PI3K/Akt/mTOR signaling pathway. Antiproliferative agent-32 inhibits Huh7 and SK-Hep-1 cells proliferation, and induce cells apoptosis, causes mitochondrial damage. Antiproliferative agent-32 can be used for research of hepatocellular carcinoma.

For research use only. We do not sell to patients.

Antiproliferative agent-32

Antiproliferative agent-32 Chemical Structure

CAS No. : 2925814-05-5

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Antiproliferative agent-32 Related Antibodies

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Description

Antiproliferative agent-32 (Compound 1c) inhibits the phosphorylation of PI3K/Akt/mTOR signaling pathway. Antiproliferative agent-32 inhibits Huh7 and SK-Hep-1 cells proliferation, and induce cells apoptosis, causes mitochondrial damage. Antiproliferative agent-32 can be used for research of hepatocellular carcinoma[1].

Cellular Effect
Cell Line Type Value Description References
HCCLM9 IC50
6.14 μM
Compound: 1c
Antiproliferative activity against human HCCLM9 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human HCCLM9 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 37182331]
HepG2 IC50
9.76 μM
Compound: 1c
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 37182331]
Huh-7 IC50
2.52 μM
Compound: 1c
Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 37182331]
SK-HEP1 IC50
4.2 μM
Compound: 1c
Antiproliferative activity against human SK-HEP1 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human SK-HEP1 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 37182331]
Molecular Weight

289.33

Formula

C19H15NO2
CAS No.
SMILES

CC(OC1=CC=CC=C1/C=C/C2=NC=CC3=CC=CC=C23)=O
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antiproliferative agent-32 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiproliferative agent-322925814-05-5Antiproliferative agent32Antiproliferative agent 32Apoptosiscancerhepatocellular carcinomaHuh7SK-Hep-1Inhibitorinhibitorinhibit

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