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Referencia número: HY-155124

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Antiproliferative agent-32

Antiproliferative agent-32 (Compound 1c) inhibits the phosphorylation of PI3K/Akt/mTOR signaling pathway. Antiproliferative agent-32 inhibits Huh7 and SK-Hep-1 cells proliferation, and induce cells apoptosis, causes mitochondrial damage. Antiproliferative agent-32 can be used for research of hepatocellular carcinoma.

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No. CAS: 2925814-05-5
Fòrmula: C₁₉H₁₅NO₂
Peso molecular:289.33

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Antiproliferative agent-32 Chemical Structure

No. CAS: 2925814-05-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
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- Cellular Effect
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Actividad biológica

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
HCCLM9	IC₅₀	6.14 μM Compound: 1c	Antiproliferative activity against human HCCLM9 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human HCCLM9 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 37182331]
HepG2	IC₅₀	9.76 μM Compound: 1c	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 37182331]
Huh-7	IC₅₀	2.52 μM Compound: 1c	Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 37182331]
SK-HEP1	IC₅₀	4.2 μM Compound: 1c	Antiproliferative activity against human SK-HEP1 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human SK-HEP1 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 37182331]

Chemical Information

No. CAS 2925814-05-5
Peso molecular 289.33
Fòrmula C₁₉H₁₅NO₂
SMILES

CC(OC1=CC=CC=C1/C=C/C2=NC=CC3=CC=CC=C23)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Wang Y, et al. Design, synthesis, and biological evaluation of 1-styrenyl isoquinoline derivatives for anti-hepatocellular carcinoma activity and effect on mitochondria. Eur J Med Chem. 2023 Aug 5;256:115420. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Antiproliferative agent-32

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Antiproliferative agent-32

Actividad biológica

Descripciòn

Cellular Effect

Chemical Information

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Antiproliferative agent-32 Related Classifications

HY-155124 Related Classifications

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