Catumaxomab
Based on 1 Customer Validation
Catumaxomab, a trifunctional IgG2 antibody, is composed of mouse and rat heavy and light chains and binds to human EpCAM and human CD 3 receptors. The Fc region of Catumaxomab region has binding affinity for FcγR1 (CD 64), FcγRIIA (CD 32a), and FcγRIII (CD 16). Catumaxomab can be used for anti-tumor research, especially epithelial cancers.
For research use only. We do not sell to patients.
- Purity: 99.82%
- CAS No.: 509077-98-9
- Molecular Weight:146.73 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
IgG2a-kappa/G2b-lambda
Human
CD3E & EPCAM
Catumaxomab (0-5 ng/mL; 3-7 days) strongly inhibits the growth of FaDu tumor spheroids in coculture with PBMC with a dose-dependent manner[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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IgG2a-kappa/G2b-lambda
ELISA, FACS, Functional assay
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Flow Cytometry analysis of Jurkat cells labelling CD3 (red) with Catumaxomab at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Mouse IgG (PE) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG. Black - Unlabelled control, cells without incubation with primary antibody. -
Immobilized EpCAM/TROP1 Protein, Human (Biotinylated, HEK293, His-Avi, HY-P72367) can bind Catumaxomab. The EC50 for this effect is 579.8 ng/mL.
Chemical Information
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CAS No. 509077-98-9
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Appearance Liquid
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Molecular Weight 146.73 kDa
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Color Colorless to light yellow
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SMILES
[Catumaxomab]
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (257 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)