1. GPCR/G Protein
  2. Angiotensin Receptor
  3. Saralasin TFA

Saralasin TFA (Synonyms: [Sar1,Ala8] Angiotensin II TFA)

Cat. No.: HY-P0205B Purity: 98.39%
Handling Instructions

Saralasin ([Sar1,Ala8] Angiotensin II) TFA is a competitive angiotensin II antagonist. Saralasin TFA is used to identify renin-dependent (angiotensinogenic) hypertension.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Saralasin TFA Chemical Structure

Saralasin TFA Chemical Structure

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 655 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 580 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Saralasin ([Sar1,Ala8] Angiotensin II) TFA is a competitive angiotensin II antagonist. Saralasin TFA is used to identify renin-dependent (angiotensinogenic) hypertension[1].

In Vitro

Saralasin ([Sar1,Ala8] Angiotensin II) TFA is an intravenously administered, competitive antagonist of angiotensin II that is used to identify renin-dependent (angiotensinogenic) hypertension[1].
Saralasin TFA (1 nmol/ml) inhibits cell growth in 3T3 and SV3T3 cells and causes an increase of cellular renin concentration[2].

In Vivo

Saralasin ([Sar1,Ala8] Angiotensin II) TFA (10 and 30 mg/kg) increases serum renin activity (SRA) in normal, conscious rats from 2.7 to 16.2 and 22.5 ng/ml/hr, respectively, without markedly altering blood pressure or heart rate. n sodium-depleted rats, Saralasin TFA (0.3 mg/kg) increased SRA from 12 to 119 ng/ml/hr and decreased blood pressure by 6%[3].

Molecular Weight

1026.07

Formula

C₄₄H₆₆F₃N₁₃O₁₂

Sequence

{Sar}{Arg}{Val}{Tyr}{Val}{His}{Pro}{Ala}

Sequence Shortening

{Sar}-RVYVHPA

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

Saralasin[Sar1,Ala8] Angiotensin IIAngiotensin Receptorcompetitiverenin-dependent3T3SV3T3cellsconsciousbloodpressureInhibitorinhibitorinhibit

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Saralasin TFA
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HY-P0205B
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