2. Anti-infection
  3. SARS-CoV
  4. SARS-CoV-2-IN-32

SARS-CoV-2-IN-32 (compound 3g) is a COVID-19 inhibitor. SARS-CoV-2-IN-32 shows anti-proliferative activity against cancer cells. SARS-CoV-2-IN-32 exhibits comparatively high binding affinity (-8.8 Kcal/mole) to COVID-19 main protease (Mpro) (PDB ID: 6LU7). SARS-CoV-2-IN-32 can be used in studies of cancer and COVID-19.

For research use only. We do not sell to patients.

SARS-CoV-2-IN-32

SARS-CoV-2-IN-32 Chemical Structure

CAS No. : 96068-42-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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SARS-CoV-2-IN-32 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

SARS-CoV-2-IN-32 (compound 3g) is a COVID-19 inhibitor. SARS-CoV-2-IN-32 shows anti-proliferative activity against cancer cells. SARS-CoV-2-IN-32 exhibits comparatively high binding affinity (-8.8 Kcal/mole) to COVID-19 main protease (Mpro) (PDB ID: 6LU7). SARS-CoV-2-IN-32 can be used in studies of cancer and COVID-19[1].

IC50 & Target

COVID-19[1].
In Vitro

SARS-CoV-2-IN-32 (0-40 µM; 48 h) exhibits antiproliferative activity in MCF-7, MDA-MB-231, HeLa and PC-3 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SARS-CoV-2-IN-32 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MCF-7, MDA-MB-231, HeLa, PC-3, Ishikawa, HEK-293
Concentration: 0-40 µM
Incubation Time: 48 h
Result: Inhibited proliferation of MCF-7, MDA-MB-231, HeLa, PC-3, Ishikawa, HEK-293 cells with IC50 values of 35.64, 39.56, 38.32, 35.38, >40 and >40 μM, respectively.
Molecular Weight

481.50

Formula

C27H23N5O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[O-][N+](C1=CC=C(C(C2=C(N(C3=CC=CC=C3)N=C2C)O)C4=C(N(C5=CC=CC=C5)N=C4C)O)C=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (103.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0768 mL 10.3842 mL 20.7684 mL
5 mM 0.4154 mL 2.0768 mL 4.1537 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0768 mL 10.3842 mL 20.7684 mL 51.9211 mL
5 mM 0.4154 mL 2.0768 mL 4.1537 mL 10.3842 mL
10 mM 0.2077 mL 1.0384 mL 2.0768 mL 5.1921 mL
15 mM 0.1385 mL 0.6923 mL 1.3846 mL 3.4614 mL
20 mM 0.1038 mL 0.5192 mL 1.0384 mL 2.5961 mL
25 mM 0.0831 mL 0.4154 mL 0.8307 mL 2.0768 mL
30 mM 0.0692 mL 0.3461 mL 0.6923 mL 1.7307 mL
40 mM 0.0519 mL 0.2596 mL 0.5192 mL 1.2980 mL
50 mM 0.0415 mL 0.2077 mL 0.4154 mL 1.0384 mL
60 mM 0.0346 mL 0.1731 mL 0.3461 mL 0.8654 mL
80 mM 0.0260 mL 0.1298 mL 0.2596 mL 0.6490 mL
100 mM 0.0208 mL 0.1038 mL 0.2077 mL 0.5192 mL
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SARS-CoV-2-IN-32 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SARS-CoV-2-IN-3296068-42-7SARS-CoVSARS coronaviruscancerMCF-7MDA-MB-231HeLaPC-3IshikawaHEK-293Inhibitorinhibitorinhibit

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