hCAIX-IN-24
hCAIX-IN-24 is a potent and selectively hCA IX inhibitor with an KI value of 32.1 nM. hCAIX-IN-24 shows anti-proliferative activity.
For research use only. We do not sell to patients.
- CAS No.: 3038222-64-6
- Formula: C23H24N2O4STe
- Molecular Weight:552.11
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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hCA IX 32.1 nM (Ki) |
hCA XII 8.1 nM (Ki) |
hCA VII 15.9 nM (Ki) |
hCA XIII 95.7 nM (Ki) |
hCAIX-IN-24 (compound 7c) (0-100 μM; 24 h) shows anti-proliferative activity with IC50s of 62.5, 0.7121, 12.11, 7.834, 2.356 μM for HDF, MeWo, LN-229, SaOS-2, HepG2 cells, respectively[1].
hCAIX-IN-24 (62.5 μM for NHDF, 2.365 μM for HepG2) induces a significant decrease in O2?- production in NHDF and HepG2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NHDF, MeWo, LN-229, SaOS-2, HepG2 cells
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Concentration:0, 5, 10, 30, 70, 100 μM
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Incubation Time:24 h
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Result:Inhibited cell growth with IC50s of 62.5, 0.7121, 12.11, 7.834, 2.356 μM for HDF, MeWo, LN-229, SaOS-2, HepG2 cells, respectively.
Chemical Information
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CAS No. 3038222-64-6
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Molecular Weight 552.11
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Formula C23H24N2O4STe
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SMILES
COC1=CC=C(C=C1)[Te]CC2=CC=C(C=C2)C(NCCC3=CC=C(C=C3)S(N)(=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
hCAIX-IN-24 Related Classifications
HY-152001 Related Classifications
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