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TP53RK Antibody (YA8357)(PBS only)

(Synonyms: BUD32; C20orf64; dJ101A2; Nori-2; Nori-2p; PRPK)

TP53RK Antibody (YA8357) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TP53RK.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    IHC-P

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • TP53RK Antibody (YA8357)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:150-500

Product Details

Description

TP53RK Antibody (YA8357) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TP53RK.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 28 kDa
Immunogen

Full length human recombinant protein of human TP53RK produced in E.coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    TP53RK component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP. Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation[1][2][3].

  • Subcellular Localization

    Cytoplasm,Nucleus

  • Expression


    Tissue_Specificity: Highly expressed in testis. Weakly expressed in heart kidney and spleen

  • Isoforms & Post-Translational Modification

    Q96S44: 253 amino acids, molecular weight 28160 Da.

  • Subunit

    Component of the EKC/KEOPS complex composed of at least GON7, TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes

  • SwissProt ID

    Q96S44

  • Synonyms

    BUD32; C20orf64; dJ101A2; Nori-2; Nori-2p; PRPK

TP53RK Antibody (YA8357)(PBS only) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • TP53RK Antibody (YA8357)(PBS only) Product Image