SSR182289
SSR182289 (SSR182289A free base) is a selective and potent orally active thrombin inhibitor. SSR182289 competitively and selectivity inhibits human thrombin (Ki=0.031 μM). SSR182289 demonstrates anticoagulant activity in vitro (thrombin time EC100=96 nM) and inhibits tissue factor-induced thrombin generation (IC50=0.15 μM) in human plasma. SSR182289 inhibits thrombin-induced aggregation of human platelets (IC50=32 nM), but has no effect on aggregation induced by other platelet agonists .
For research use only. We do not sell to patients.
- CAS No.: 363151-21-7
- Formula: C30H33F2N5O4S
- Molecular Weight:597.68
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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human Thrombin 0.031 nM (Ki) |
Trypsin 54 nM (Ki) |
Factor VIIa/tissue factor 167 μM (Ki) |
Factor IXa >250 μM (Ki) |
Factor Xa >250 μM (Ki) |
Plasmin >250 μM (Ki) |
Urokinase >250 μM (Ki) |
tPA >250 μM (Ki) |
Kallikrein >250 μM (Ki) |
Activated protein C >250 μM (Ki) |
Chemical Information
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CAS No. 363151-21-7
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Molecular Weight 597.68
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Formula C30H33F2N5O4S
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SMILES
CC(NC1=C(S(=O)(N[C@H](C(N2CC/C(CC2)=C(F)/F)=O)CCCC3=NC=C(N)C=C3)=O)C=CC=C1C4=CC=CC=C4)=O
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Synonyms
SSR182289A free base
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Jean-Michel Altenburger, et al. SSR182289A, a selective and potent orally active thrombin inhibitor. Bioorg Med Chem. 2004 Apr 1;12(7):1713-30. [Content Brief]
[2]. Jean-Michel Altenburger, et al. SSR182289A, a selective and potent orally active thrombin inhibitor. Bioorg Med Chem. 2004 Apr 1;12(7):1713-30. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SSR182289 Related Classifications
HY-19674 Related Classifications
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