2. Immunology/Inflammation GPCR/G Protein Membrane Transporter/Ion Channel
  3. CCR Potassium Channel P-glycoprotein
  4. AZD-5672

AZD-5672 is an orally active, potent, and selective CCR5 antagonist (IC50=0.32 nM). AZD-5672 shows moderate activity against the hERG ion channel (binding IC50=7.3 μM). AZD5672 is a substrate of human P-gp, and inhibits P-gp-mediated digoxin transport (IC50=32 μM). AZD-5672 can be used for the research of rheumatoid arthritis.

For research use only. We do not sell to patients.

AZD-5672 Chemical Structure

AZD-5672 Chemical Structure

CAS No. : 780750-65-4

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 715 In-stock
Solution
10 mM * 1 mL in DMSO USD 715 In-stock
Solid
5 mg USD 650 In-stock
10 mg USD 1050 In-stock
25 mg USD 2250 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

AZD-5672 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE AZD-5672

View All CCR Isoform Specific Products:

View All Isoforms
CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

AZD-5672 is an orally active, potent, and selective CCR5 antagonist (IC50=0.32 nM). AZD-5672 shows moderate activity against the hERG ion channel (binding IC50=7.3 μM). AZD5672 is a substrate of human P-gp, and inhibits P-gp-mediated digoxin transport (IC50=32 μM). AZD-5672 can be used for the research of rheumatoid arthritis[1][2][3].

IC50 & Target[1][2]

CCR5

0.32 nM (IC50)

hERG

7.3 μM (IC50)

hP-gp

32 μM (IC50)

In Vitro

AZD-5672 (0, 0.1, 0.3, 1, 3, 10, 30, and 100 μM) inhibits P-gp-mediated digoxin transport in a concentration-dependent manner (mean apparent IC50: 32 μM) in Caco-2 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AZD-5672 Related Antibodies
In Vivo

In vivo pharmaeokineties data for AZD-5672 (compound 1)[1]

Species CIa
(mL/min/kg)		 Vssa (L/kg) t1/2a (h) Fb (%)
Rat 28 5.3 2.6 38
Dog 18 5.7 3.9 86

a AZD-5672 dosed 1-2 mg/kg i.v.
b AZD-5672 dosed 2-5 mg/kg p.o.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

632.78

Formula

C32H38F2N2O5S2
CAS No.
Appearance

Solid

Color

Light brown to gray

SMILES

O=C(N(C1CCN(CC[C@@H](C2=CC(F)=CC(F)=C2)C3=CC=C(S(=O)(C)=O)C=C3)CC1)CC)CC4=CC=C(S(=O)(C)=O)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (52.67 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5803 mL 7.9016 mL 15.8033 mL
5 mM 0.3161 mL 1.5803 mL 3.1607 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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V1

=
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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5803 mL 7.9016 mL 15.8033 mL 39.5082 mL
5 mM 0.3161 mL 1.5803 mL 3.1607 mL 7.9016 mL
10 mM 0.1580 mL 0.7902 mL 1.5803 mL 3.9508 mL
15 mM 0.1054 mL 0.5268 mL 1.0536 mL 2.6339 mL
20 mM 0.0790 mL 0.3951 mL 0.7902 mL 1.9754 mL
25 mM 0.0632 mL 0.3161 mL 0.6321 mL 1.5803 mL
30 mM 0.0527 mL 0.2634 mL 0.5268 mL 1.3169 mL
40 mM 0.0395 mL 0.1975 mL 0.3951 mL 0.9877 mL
50 mM 0.0316 mL 0.1580 mL 0.3161 mL 0.7902 mL
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AZD-5672 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZD-5672780750-65-4AZD5672AZD 5672CCRPotassium ChannelP-glycoproteinCC chemokine receptorKcsAP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243rheumatoid arthritisorally activepotentselectivesubstratedigoxin transportInhibitorinhibitorinhibit

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