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Cat. No.: HY-156202

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Geranylgeranoic acid

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Based on 1 Customer Validation

Geranylgeranoic acid (Compound 5) is inhibits lysine-specific demethylase 1 (LSD1) with an IC₅₀ value of 46.97 µM. Geranylgeranoic acid induces apoptosis via loss of the mitochondrial membrane potential and activation of interleukin-1β-converting enzyme (ICE) and cysteine protease precursor 32 (CPP32) in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes. Geranylgeranoic acid an isoprenoid with anticancer activity, which is found in S. chinensis.

For research use only. We do not sell to patients.

Purity: 98.1%
CAS No.: 35750-48-2
Formula: C₂₀H₃₂O₂
Molecular Weight:304.47

Storage:

Solution, -20°C, 2 years

Geranylgeranoic acid Chemical Structure

CAS No.: 35750-48-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Histone Demethylase Isoforms :

Chemical Information

CAS No. 35750-48-2
Appearance Liquid
Molecular Weight 304.47
Formula C₂₀H₃₂O₂
Color Colorless to light yellow
SMILES

C/C(C)=C\CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ungur N, et al. Synthetic studies on natural diterpenoid glyceryl esters[J]. Tetrahedron, 2000, 56(16): 2503-2512.

[2]. Shidoji Y, et al. Rapid loss in the mitochondrial membrane potential during geranylgeranoic acid-induced apoptosis. Biochem Biophys Res Commun. 1997 Jan 3;230(1):58-63. [Content Brief]

[3]. Sakane C, et al. Inhibition of lysine-specific demethylase 1 by the acyclic diterpenoid geranylgeranoic acid and its derivatives. Biochem Biophys Res Commun. 2014 Jan 31;444(1):24-9. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Geranylgeranoic acid

All Histone Demethylase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Geranylgeranoic acid Related Classifications

HY-156202 Related Classifications