Geranylgeranoic acid

Cat. No.: HY-156202 Purity: 98.1%: Data Sheet
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Geranylgeranoic acid (Compound 5) is inhibits lysine-specific demethylase 1 (LSD1) with an IC₅₀ value of 46.97 µM. Geranylgeranoic acid induces apoptosis via loss of the mitochondrial membrane potential and activation of interleukin-1β-converting enzyme (ICE) and cysteine protease precursor 32 (CPP32) in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes. Geranylgeranoic acid an isoprenoid with anticancer activity, which is found in S. chinensis.

For research use only. We do not sell to patients.

Geranylgeranoic acid Chemical Structure

CAS No. : 35750-48-2

Size	Stock	Quantity
Solvent
100 μg (3.28 mM * 100 μL in Methyl acetate)	In-stock	Estimated Time of Arrival: December 31
Solvent
500 μg (3.28 mM * 500 μL in Methyl acetate)	In-stock	Estimated Time of Arrival: December 31

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Based on 1 publication(s) in Google Scholar

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Description	Geranylgeranoic acid (Compound 5) is inhibits lysine-specific demethylase 1 (LSD1) with an IC₅₀ value of 46.97 µM. Geranylgeranoic acid induces apoptosis via loss of the mitochondrial membrane potential and activation of interleukin-1β-converting enzyme (ICE) and cysteine protease precursor 32 (CPP32) in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes. Geranylgeranoic acid an isoprenoid with anticancer activity, which is found in S. chinensis^[1]^[2]^[3].
Molecular Weight	304.47
Formula	C₂₀H₃₂O₂
CAS No.	35750-48-2
Appearance	Liquid
Color	Colorless to light yellow
SMILES	C/C(C)=C\CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/C(O)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Solution, -20°C, 2 years
Purity & Documentation	Purity: 98.1% Select Batch: Data Sheet (262 KB) SDS (252 KB) COA (239 KB) Handling Instructions (2659 KB)
References	[1]. Ungur N, et al. Synthetic studies on natural diterpenoid glyceryl esters[J]. Tetrahedron, 2000, 56(16): 2503-2512. [2]. Shidoji Y, et al. Rapid loss in the mitochondrial membrane potential during geranylgeranoic acid-induced apoptosis. Biochem Biophys Res Commun. 1997 Jan 3;230(1):58-63. [Content Brief] [3]. Sakane C, et al. Inhibition of lysine-specific demethylase 1 by the acyclic diterpenoid geranylgeranoic acid and its derivatives. Biochem Biophys Res Commun. 2014 Jan 31;444(1):24-9. [Content Brief]