1. Antibody-drug Conjugate/ADC Related
  2. ADC Cytotoxin
  3. DC1SMe

DC1SMe 

Cat. No.: HY-112898 Purity: >98.0%
Handling Instructions

DC1Sme, a DC1 derivative, exhibits IC50 values of 22 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa, HL60/s and COLO 205 cancer cells, respectively. DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is a ADC Cytotoxin. DC1 can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer.

For research use only. We do not sell to patients.

DC1SMe Chemical Structure

DC1SMe Chemical Structure

CAS No. : 501666-85-9

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 828 In-stock
Estimated Time of Arrival: December 31
5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 3150 Get quote
100 mg USD 5700 Get quote
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

DC1Sme, a DC1 derivative, exhibits IC50 values of 22 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa, HL60/s and COLO 205 cancer cells, respectively. DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is a ADC Cytotoxin. DC1 can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer.

IC50 & Target

Duocarmycins

 

Molecular Weight

684.23

Formula

C₃₅H₃₀ClN₅O₄S₂

CAS No.

501666-85-9

SMILES

O=C(C(N1)=CC2=C1C=CC(NC(CCSSC)=O)=C2)NC3=CC4=C(NC(C(N5C[[email protected]@H](CCl)C6=C5C=C(O)C7=CC=CC=C67)=O)=C4)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

References

Purity: >98.0%

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

DC1SMeADC CytotoxinInhibitorinhibitorinhibit

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DC1SMe
Cat. No.:
HY-112898
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