DC1SMe
Based on 1 Customer Validation
DC1Sme, a DC1 derivative, exhibits IC50 values of 22 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa, HL60/s and COLO 205 cancer cells, respectively. DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is a ADC Cytotoxin. DC1 can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 501666-85-9
- Formula: C35H30ClN5O4S2
- Molecular Weight:684.23
-
Storage:
-20°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Duocarmycins |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| COLO 205 | IC50 |
250 pM
Compound: 23, DC1SMe
|
Cytotoxicity against human COLO205 cells assessed as cell survival after 72 hrs by clonogenic assay
Cytotoxicity against human COLO205 cells assessed as cell survival after 72 hrs by clonogenic assay
|
[PMID: 22148292] |
| HL-60 | IC50 |
32 pM
Compound: 23, DC1SMe
|
Cytotoxicity against human HL60 cells assessed as cell survival after 72 hrs by clonogenic assay
Cytotoxicity against human HL60 cells assessed as cell survival after 72 hrs by clonogenic assay
|
[PMID: 22148292] |
| NAMALVA | IC50 |
10 pM
Compound: 23, DC1SMe
|
Cytotoxicity against human NAMALWA cells assessed as cell survival after 72 hrs by clonogenic assay
Cytotoxicity against human NAMALWA cells assessed as cell survival after 72 hrs by clonogenic assay
|
[PMID: 22148292] |
| Ramos | IC50 |
22 pM
Compound: 23, DC1SMe
|
Cytotoxicity against human Ramos cells assessed as cell survival after 72 hrs by clonogenic assay
Cytotoxicity against human Ramos cells assessed as cell survival after 72 hrs by clonogenic assay
|
[PMID: 22148292] |
Chemical Information
-
CAS No. 501666-85-9
-
Appearance Solid
-
Molecular Weight 684.23
-
Formula C35H30ClN5O4S2
-
Color Light yellow to yellow
-
SMILES
O=C(C(N1)=CC2=C1C=CC(NC(CCSSC)=O)=C2)NC3=CC4=C(NC(C(N5C[C@@H](CCl)C6=C5C=C(O)C7=CC=CC=C67)=O)=C4)C=C3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Purity & Documentation
-
Data Sheet (266 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DC1SMe Related Classifications
HY-112898 Related Classifications
Powered by Bioz