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  3. ML347

ML347 (Synonyms: LDN 193719)

Cat. No.: HY-12274 Purity: 99.95%
Handling Instructions

ML347(DN193719) is a highly selective ALK1/ALK2 inhibitor with IC50s of 46/32 nM; shows >300-fold selectivity for ALK2 vs.

For research use only. We do not sell to patients.

ML347 Chemical Structure

ML347 Chemical Structure

CAS No. : 1062368-49-3

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10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
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Estimated Time of Arrival: December 31
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10 mg USD 90 In-stock
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50 mg USD 350 In-stock
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100 mg USD 600 In-stock
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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

    ML347 purchased from MCE. Usage Cited in: Patent. US20170369886A1.

    FIG illustrates angiogenesis in the absence and presence of an Alk1 small molecule inhibitor (ML347) in presence or absence of inhibin α.

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    Description

    ML347(DN193719) is a highly selective ALK1/ALK2 inhibitor with IC50s of 46/32 nM; shows >300-fold selectivity for ALK2 vs. ALK3. IC50 value: Target: ALK1/ALK2 ML347 has IC50’s of 46 and 32 nM, respectively, against ALK1 and ALK2; however, the IC50 against ALK3 is 10,800 nM, >300-fold selective over ALK3. ML347 is completely inactive against all the other kinases tested (with weak activity against ALK6, 9830 nM and KDR (VEGFR2)19,700 nM). ML347 is potent in the BMP4 cell assay (152 nM).

    Molecular Weight

    352.39

    Formula

    C₂₂H₁₆N₄O

    CAS No.
    SMILES

    COC1=CC=C(C2=CN3C(N=C2)=C(C4=C5C=CC=NC5=CC=C4)C=N3)C=C1

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 10 mg/mL (28.38 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.8378 mL 14.1888 mL 28.3776 mL
    5 mM 0.5676 mL 2.8378 mL 5.6755 mL
    10 mM 0.2838 mL 1.4189 mL 2.8378 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References

    Purity: 99.95%

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    Keywords:

    ML347LDN 193719ML 347ML-347LDN193719LDN-193719TGF-β ReceptorTransforming growth factor beta receptorsInhibitorinhibitorinhibit

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    Product Name:
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    Cat. No.:
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