1. TGF-beta/Smad
  2. TGF-β Receptor
  3. ML347

ML347  (Synonyms: LDN 193719)

Cat. No.: HY-12274 Purity: 99.89%
COA Handling Instructions

ML347 (LDN193719) is a highly selective ALK1/ALK2 inhibitor. ML347 has IC50 values of 46 and 32 nM against ALK1 and ALK2, respectively, >300-fold selective over ALK3. ML347 block the phosphorylation of Smad1/5 by TGF-β1.

For research use only. We do not sell to patients.

ML347 Chemical Structure

ML347 Chemical Structure

CAS No. : 1062368-49-3

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
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10 mM * 1 mL in DMSO USD 73 In-stock
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Customer Review

Based on 6 publication(s) in Google Scholar

Top Publications Citing Use of Products

    ML347 purchased from MedChemExpress. Usage Cited in: Patent. US20170369886A1.

    FIG illustrates angiogenesis in the absence and presence of an Alk1 small molecule inhibitor (ML347) in presence or absence of inhibin α.

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    • Customer Review


    ML347 (LDN193719) is a highly selective ALK1/ALK2 inhibitor. ML347 has IC50 values of 46 and 32 nM against ALK1 and ALK2, respectively, >300-fold selective over ALK3. ML347 block the phosphorylation of Smad1/5 by TGF-β1[1][2].

    IC50 & Target[1]


    46 nM (IC50)


    32 nM (IC50)


    10800 nM (IC50)

    In Vitro

    ML347 can inhibit ALK1/ALK2 to block TGF?β signal transduction[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.


    Cell Line: Primary dental epithelial cells were cultured in Dulbecco’s Modifed Eagle Medium (DMEM)/ F12 supplemented with 20% fetal bovine serum and 1% penicillin/streptomycin.
    Concentration: 25 μM
    Incubation Time: 2 hours
    Result: Inhibited ALK1/ALK2 then blocking Smad1/5 by TGF-β1.
    Molecular Weight




    CAS No.



    Light yellow to yellow




    Room temperature in continental US; may vary elsewhere.

    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 10 mg/mL (28.38 mM; Need ultrasonic)

    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.8378 mL 14.1888 mL 28.3776 mL
    5 mM 0.5676 mL 2.8378 mL 5.6755 mL
    10 mM 0.2838 mL 1.4189 mL 2.8378 mL
    *Please refer to the solubility information to select the appropriate solvent.
    Purity & Documentation

    Purity: 99.89%

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    ML347 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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