1. TGF-beta/Smad
  2. TGF-β Receptor

ML347 (Synonyms: LDN 193719)

Cat. No.: HY-12274 Purity: 99.94%
Handling Instructions

ML347(DN193719) is a highly selective ALK1/ALK2 inhibitor with IC50s of 46/32 nM; shows >300-fold selectivity for ALK2 vs.

For research use only. We do not sell to patients.
ML347 Chemical Structure

ML347 Chemical Structure

CAS No. : 1062368-49-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 79 In-stock
5 mg USD 72 In-stock
10 mg USD 108 In-stock
50 mg USD 420 In-stock
100 mg   Get quote  
200 mg   Get quote  

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    ML347 purchased from MCE. Usage Cited in: Patent. US 20170369886 A1.

    FIG illustrates angiogenesis in the absence and presence of an Alk1 small molecule inhibitor (ML347) in presence or absence of inhibin α.
    • Biological Activity

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    • References


    ML347(DN193719) is a highly selective ALK1/ALK2 inhibitor with IC50s of 46/32 nM; shows >300-fold selectivity for ALK2 vs. ALK3. IC50 value: Target: ALK1/ALK2 ML347 has IC50’s of 46 and 32 nM, respectively, against ALK1 and ALK2; however, the IC50 against ALK3 is 10,800 nM, >300-fold selective over ALK3. ML347 is completely inactive against all the other kinases tested (with weak activity against ALK6, 9830 nM and KDR (VEGFR2)19,700 nM). ML347 is potent in the BMP4 cell assay (152 nM).

    Preparing Stock Solutions
    Concentration Volume Mass 1 mg 5 mg 10 mg
    1 mM 2.8378 mL 14.1888 mL 28.3776 mL
    5 mM 0.5676 mL 2.8378 mL 5.6755 mL
    10 mM 0.2838 mL 1.4189 mL 2.8378 mL
    Please refer to the solubility information to select the appropriate solvent.
    Molecular Weight




    CAS No.




    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month

    Room temperature in continental US; may vary elsewhere

    Solvent & Solubility

    DMSO: 6.2 mg/mL (Need ultrasonic)

    * "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

    Purity: 99.94%

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