HSD17B13-IN-104
HSD17B13-IN-104 (Compound 32) is an orally active, highly potent and selective HSD17B13 inhibitor (IC50=2.5 nM). HSD17B13-IN-104 regulates hepatic lipid metabolism by inhibiting the SREBP-1c/FAS pathway. HSD17B13-IN-104 blocks HSD17B13 enzymatic activity to improve hepatic lipid accumulation. HSD17B13-IN-104 is promising for research of metabolic dysfunction-associated steatohepatitis.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 3075100-76-1
- Formula: C21H18ClF3N2O2S
- Molecular Weight:454.89
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All 17β-HSD Isoforms
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Biological Activity
Chemical Information
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CAS No. 3075100-76-1
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Appearance Solid
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Molecular Weight 454.89
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Formula C21H18ClF3N2O2S
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Color White to off-white
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SMILES
O=C(C1=C(C)N=C(S1)C2=CC(F)=C(F)C(O)=C2F)N(C(C)C)CC3=CC=C(C=C3)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (109.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1983 mL | 10.9917 mL | 21.9833 mL | 54.9583 mL |
| 5 mM | 0.4397 mL | 2.1983 mL | 4.3967 mL | 10.9917 mL | |
| 10 mM | 0.2198 mL | 1.0992 mL | 2.1983 mL | 5.4958 mL | |
| 15 mM | 0.1466 mL | 0.7328 mL | 1.4656 mL | 3.6639 mL | |
| 20 mM | 0.1099 mL | 0.5496 mL | 1.0992 mL | 2.7479 mL | |
| 25 mM | 0.0879 mL | 0.4397 mL | 0.8793 mL | 2.1983 mL | |
| 30 mM | 0.0733 mL | 0.3664 mL | 0.7328 mL | 1.8319 mL | |
| 40 mM | 0.0550 mL | 0.2748 mL | 0.5496 mL | 1.3740 mL | |
| 50 mM | 0.0440 mL | 0.2198 mL | 0.4397 mL | 1.0992 mL | |
| 60 mM | 0.0366 mL | 0.1832 mL | 0.3664 mL | 0.9160 mL | |
| 80 mM | 0.0275 mL | 0.1374 mL | 0.2748 mL | 0.6870 mL | |
| 100 mM | 0.0220 mL | 0.1099 mL | 0.2198 mL | 0.5496 mL |
HSD17B13-IN-104 Related Classifications
HY-174133 Related Classifications
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