3075100-76-1
3075100-76-1
Chemical Structure
HSD17B13-IN-104
- CAS No.: 3075100-76-1
- Formula:C21H18ClF3N2O2S
- Molecular Weight:454.89
SMILES: O=C(C1=C(C)N=C(S1)C2=CC(F)=C(F)C(O)=C2F)N(C(C)C)CC3=CC=C(C=C3)Cl
Biological Activity: HSD17B13-IN-104 (Compound 32) is an orally active, highly potent and selective HSD17B13 inhibitor (IC50=2.5 nM). HSD17B13-IN-104 regulates hepatic lipid metabolism by inhibiting the SREBP-1c/FAS pathway. HSD17B13-IN-104 blocks HSD17B13 enzymatic activity to improve hepatic lipid accumulation. HSD17B13-IN-104 is promising for research of metabolic dysfunction-associated steatohepatitis[1].
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HSD17B13-IN-104 | 95.0% | HSD17B13-IN-104 (Compound 32) is an orally active, highly potent and selective HSD17B13 inhibitor (IC50=2.5 nM). HSD17B13-IN-104 regulates hepatic lipid metabolism by inhibiting the SREBP-1c/FAS pathway. HSD17B13-IN-104 blocks HSD17B13 enzymatic activity to improve hepatic lipid accumulation. HSD17B13-IN-104 is promising for research of metabolic dysfunction-associated steatohepatitis. | ||||||||||||||||||||
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References
Keywords
