2. Protein Tyrosine Kinase/RTK Stem Cell/Wnt MAPK/ERK Pathway
  3. FGFR ERK
  4. TCB-32

TCB-32 (Compound I-1) is a FGFR1 agonist with an EC50 of 0.88  μM. TCB-32 significantly increases cell proliferation through activating FGFR1 signaling pathway as bFGF and its downstream ERK1/2 with excellent thermal stability. TCB-32 can replace bFGF in serum-free cell culture media. TCB-32 can be used for tissue repair and wound healing related diseases like psoriasis and eczema research.

For research use only. We do not sell to patients.

TCB-32

TCB-32 Chemical Structure

CAS No. : 352513-86-1

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Based on 1 publication(s) in Google Scholar

Other Forms of TCB-32:

TCB-32 Related Antibodies

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ERK ERK1 ERK2 ERK5 ERK8

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Description

TCB-32 (Compound I-1) is a FGFR1 agonist with an EC50 of 0.88  μM. TCB-32 significantly increases cell proliferation through activating FGFR1 signaling pathway as bFGF and its downstream ERK1/2 with excellent thermal stability. TCB-32 can replace bFGF in serum-free cell culture media. TCB-32 can be used for tissue repair and wound healing related diseases like psoriasis and eczema research[1][2].

IC50 & Target[1]

FGFR1

0.88 μM (EC50)

ERK1

 

ERK2

 

Molecular Weight

708.78

Formula

C32H40N18O2
CAS No.
SMILES

C/C(C1=CC(NC(C2=CC(C(NC3=CC(/C(C)=N/NC(N)=N)=CC(/C(C)=N/NC(N)=N)=C3)=O)=CC=C2)=O)=CC(/C(C)=N/NC(N)=N)=C1)=N\NC(N)=N
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TCB-32 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TCB-32352513-86-1TCB32TCB 32FGFRERKFibroblast growth factor receptorExtracellular signal regulated kinasesFGFR1ERK 1/2bFGFTissue repairWound healingPsoriasisEczemaInhibitorinhibitorinhibit

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