1. Protein Tyrosine Kinase/RTK
  2. FLT3
  3. FLT3-IN-11

FLT3-IN-11 

Cat. No.: HY-143894
Handling Instructions

FLT3-IN-11 (compound 30) is a potent, selective and orally active FLT3 kinase inhibitor with IC50s of 7.22 nM and 4.95 nM for wild-type FLT3 and FLT3-D835Y, respectively. FLT3-IN-11 high selectivity for FLT3 over c-KIT (>1000-fold). FLT3-IN-11has excellent anti-acute myeloid leukemia (AML) activity (MV4-11 cells, IC50 of 3.2 nM).

For research use only. We do not sell to patients.

FLT3-IN-11 Chemical Structure

FLT3-IN-11 Chemical Structure

CAS No. : 2499966-50-4

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Description

FLT3-IN-11 (compound 30) is a potent, selective and orally active FLT3 kinase inhibitor with IC50s of 7.22 nM and 4.95 nM for wild-type FLT3 and FLT3-D835Y, respectively. FLT3-IN-11 high selectivity for FLT3 over c-KIT (>1000-fold). FLT3-IN-11has excellent anti-acute myeloid leukemia (AML) activity (MV4-11 cells, IC50 of 3.2 nM)[1].

IC50 & Target

IC50: 7.22 nM (wild-type FLT3) and 4.95 nM (FLT3-D835Y)[1]

In Vitro

FLT3-IN-11 (compound 30) efficiently inhibits the growth of multiple mutant BaF3 cells expressing FLT3-ITD, FLT3-D835V/F, FLT3-F691L, FLT3-ITD-F691L, and FLT3-ITD-D835Y[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Oral administration of FLT3-IN-11 (compound 30) at 6 mg/kg/d could significantly suppress tumor growth in the MV4-11 cell-inoculated xenograft model, exhibiting tumor growth inhibitory rates of 83.5%[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

422.45

Formula

C20H25F3N6O

CAS No.
SMILES

FC(F)(F)C(C(N[[email protected]@H]1CC[[email protected]@H](CC1)N)=N2)=CN=C2NC3=CC=C(C=C3)C(N(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Product Name:
FLT3-IN-11
Cat. No.:
HY-143894
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