2499966-50-4
Chemical Structure
FLT3-IN-11
- CAS No.: 2499966-50-4
- Formula:C20H25F3N6O
- Molecular Weight:422.45
IUPAC Name: 4-((4-(((1s,4s)-4-aminocyclohexyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-N,N-dimethylbenzamide
InChIKey: ZFKQQXLECNVLOF-OKILXGFUSA-N
SMILES: FC(F)(F)C(C(N[C@@H]1CC[C@@H](CC1)N)=N2)=CN=C2NC3=CC=C(C=C3)C(N(C)C)=O
Biological Activity: FLT3-IN-11 (compound 30) is a potent, selective and orally active FLT3 kinase inhibitor with IC50s of 7.22 nM and 4.95 nM for wild-type FLT3 and FLT3-D835Y, respectively. FLT3-IN-11 high selectivity for FLT3 over c-KIT (>1000-fold). FLT3-IN-11has excellent anti-acute myeloid leukemia (AML) activity (MV4-11 cells, IC50 of 3.2 nM)[1].
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FLT3-IN-11 | FLT3-IN-11 (compound 30) is a potent, selective and orally active FLT3 kinase inhibitor with IC50s of 7.22 nM and 4.95 nM for wild-type FLT3 and FLT3-D835Y, respectively. FLT3-IN-11 high selectivity for FLT3 over c-KIT (>1000-fold). FLT3-IN-11has excellent anti-acute myeloid leukemia (AML) activity (MV4-11 cells, IC50 of 3.2 nM). | |||||||||||||||||||||
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