ML243
ML243 is a selective small-molecule inhibitor of breast cancer stem cells. ML243 has 32-fold greater selective inhibition in the breast CSC-like cell line HMLE_shECad than the control cell line HMLE_shGFP. ML243 may target the Wnt pathway at the protein level without altering RNA expression levels.
For research use only. We do not sell to patients.
- CAS No.: 1426576-80-8
- Formula: C14H16N2OS
- Molecular Weight:260.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Breast CSCs[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HMLE | EC50 |
2 μM
Compound: 19d, ML243
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Cytotoxicity against human CSC-like HMLE cells expressing shRNA and epithelial cadherin after 70 to 74 hrs by Cell Titer Glo assay
Cytotoxicity against human CSC-like HMLE cells expressing shRNA and epithelial cadherin after 70 to 74 hrs by Cell Titer Glo assay
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[PMID: 23403082] |
| HMLE | EC50 |
63.98 μM
Compound: 19d, ML243
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Cytotoxicity against human HMLE cells expressing shRNA and GFP after 70 to 74 hrs by Cell Titer Glo assay
Cytotoxicity against human HMLE cells expressing shRNA and GFP after 70 to 74 hrs by Cell Titer Glo assay
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[PMID: 23403082] |
Chemical Information
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CAS No. 1426576-80-8
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Molecular Weight 260.35
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Formula C14H16N2OS
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SMILES
CCC1=CC=C(/C=C/C(NC2=NCCS2)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ML243 Related Classifications
HY-19972 Related Classifications
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