2. Recombinant Proteins
  3. CD Antigens Fc Receptors Biotinylated Proteins
  4. Macrophage CD Proteins Monocyte CD Proteins Platelet CD Proteins Dendritic Cell CD Proteins Fc-gamma Receptor
  5. Fc gamma RII/CD32 FCGR2A/CD32a
  6. FCGR2A/CD32a
  7. Fc gamma RIIA/CD32a Protein, Human (183a.a, HEK293, His-Avi)

Fc gamma RIIA/CD32a Protein, Human (183a.a, HEK293, His-Avi)

Cat. No.: HY-P78423
Handling Instructions

Fc gamma RIIA/CD32a Protein plays a pivotal role, specifically binding to the Fc region of immunoglobulins gamma as a low-affinity receptor. Interacting with IgG, it initiates cellular responses against pathogens, crucial for immune modulation. Notably, the protein promotes opsonized antigen phagocytosis, contributing to immune defense. Engaging with IGHG1, INPP5D/SHIP1, INPPL1/SHIP2, APCS, FGR, and HCK, it participates in intricate signaling pathways, highlighting its multifaceted role in orchestrating diverse immune responses. Fc gamma RIIA/CD32a Protein, Human (183a.a, HEK293, His-Avi) is the recombinant human-derived Fc gamma RIIA/CD32a protein, expressed by HEK293 , with C-Avi, C-His labeled tag and H167 mutation. The total length of Fc gamma RIIA/CD32a Protein, Human (183a.a, HEK293, His-Avi) is 183 a.a., with molecular weight of 30-40 kDa.

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Description

Fc gamma RIIA/CD32a Protein plays a pivotal role, specifically binding to the Fc region of immunoglobulins gamma as a low-affinity receptor. Interacting with IgG, it initiates cellular responses against pathogens, crucial for immune modulation. Notably, the protein promotes opsonized antigen phagocytosis, contributing to immune defense. Engaging with IGHG1, INPP5D/SHIP1, INPPL1/SHIP2, APCS, FGR, and HCK, it participates in intricate signaling pathways, highlighting its multifaceted role in orchestrating diverse immune responses. Fc gamma RIIA/CD32a Protein, Human (183a.a, HEK293, His-Avi) is the recombinant human-derived Fc gamma RIIA/CD32a protein, expressed by HEK293 , with C-Avi, C-His labeled tag and H167 mutation. The total length of Fc gamma RIIA/CD32a Protein, Human (183a.a, HEK293, His-Avi) is 183 a.a., with molecular weight of 30-40 kDa.
Background

The Fc gamma RIIA/CD32a protein assumes a pivotal role by specifically binding to the Fc region of immunoglobulins gamma, functioning as a low-affinity receptor. Through its interaction with IgG, Fc gamma RIIA/CD32a initiates cellular responses against pathogens and soluble antigens, illustrating its crucial involvement in immune modulation. Notably, the protein promotes the phagocytosis of opsonized antigens, further contributing to immune defense mechanisms. Additionally, Fc gamma RIIA/CD32a engages in interactions with IGHG1, INPP5D/SHIP1, INPPL1/SHIP2, APCS, FGR, and HCK, indicating its participation in intricate signaling pathways and the regulation of its cellular functions. These multifaceted interactions underscore the significance of Fc gamma RIIA/CD32a in orchestrating diverse immune responses.
Species

Human
Source

HEK293
Tag

C-Avi;C-His
Accession

P12318 (A36-I218, H167)
Gene ID
Molecular Construction
N-term
CD32a (A36-I218, H167)
Accession # P12318
His-Avi
C-term
Synonyms
CD32MGC23887; CDw32fc-gamma-RIIa; Fc gamma RIIA; FCG2; Fc-gamma-RIIa; FcGR; FCGR2; FCGR2A; FCGR2A1; FcgRIIA; FCRIIA; fcRII-a; IGFR2MGC30032; IgG Fc receptor II-a; FCG2; CD32A
Molecular Weight

30-40 kDa
Purity

Greater than 95% as determined by Tris-Bis PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

Fc gamma RIIA/CD32a Protein, Human (183a.a, HEK293, His-Avi) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
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Fc gamma RIIA/CD32a Protein, Human (183a.a, HEK293, His-Avi)
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