P5SA-2

Cat. No.: HY-171177 Purity: 99.51%: Data Sheet
COA

SDS
Handling Instructions
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Technical Support

P5SA-2 is a selective allosteric activator of PPP5C. P5SA-2 exerts its effects by modulating the phosphatase domain of PPP5C and can increase PPP5C activity by 3.2-fold at 100 μM with an apparent affinity constant of 7.8 μM. P5SA-2 can be used in cancer and Alzheimer's disease research.

For research use only. We do not sell to patients.

P5SA-2 Chemical Structure

CAS No. : 864717-20-4

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

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Description

Molecular Weight

330.77

Formula

C₁₇H₁₅ClN₂O₃

CAS No.

864717-20-4

Appearance

Solid

Color

Off-white to light yellow

SMILES

ClC1=CC=C(CC2=NOC(C3=CC(OC)=C(OC)C=C3)=N2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (302.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0232 mL	15.1162 mL	30.2325 mL
5 mM	0.6046 mL	3.0232 mL	6.0465 mL
10 mM	0.3023 mL	1.5116 mL	3.0232 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.51%

Select Batch:

Data Sheet (270 KB) SDS (251 KB)

COA (251 KB) HNMR (305 KB) LCMS (92 KB)

Handling Instructions (2659 KB)

References

[1]. Zhang H, et al. Dual function of protein phosphatase 5 (PPP5C): An emerging therapeutic target for drug discovery. Eur J Med Chem. 2023 Jun 5;254:115350. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0232 mL	15.1162 mL	30.2325 mL	75.5812 mL
	5 mM	0.6046 mL	3.0232 mL	6.0465 mL	15.1162 mL
	10 mM	0.3023 mL	1.5116 mL	3.0232 mL	7.5581 mL
	15 mM	0.2015 mL	1.0077 mL	2.0155 mL	5.0387 mL
	20 mM	0.1512 mL	0.7558 mL	1.5116 mL	3.7791 mL
	25 mM	0.1209 mL	0.6046 mL	1.2093 mL	3.0232 mL
	30 mM	0.1008 mL	0.5039 mL	1.0077 mL	2.5194 mL
	40 mM	0.0756 mL	0.3779 mL	0.7558 mL	1.8895 mL
	50 mM	0.0605 mL	0.3023 mL	0.6046 mL	1.5116 mL
	60 mM	0.0504 mL	0.2519 mL	0.5039 mL	1.2597 mL
	80 mM	0.0378 mL	0.1890 mL	0.3779 mL	0.9448 mL
	100 mM	0.0302 mL	0.1512 mL	0.3023 mL	0.7558 mL

P5SA-2 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P5SA-2864717-20-4PhosphataseAllosteric activatorsphosphatase domainsapparent affinity constantscancerAlzheimer's diseaseInhibitorinhibitorinhibit

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P5SA-2

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