1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. Cav 3.2 inhibitor 1

Cav 3.2 inhibitor 1 

Cat. No.: HY-151450
Handling Instructions

Cav 3.2 inhibitor 1 is a T-type calcium channel inhibitor with little binding affinity to dopamine D2 receptors. Cav 3.2 inhibitor 1 can be used for the research of somatic and visceral pain.

For research use only. We do not sell to patients.

Cav 3.2 inhibitor 1 Chemical Structure

Cav 3.2 inhibitor 1 Chemical Structure

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Description

Cav 3.2 inhibitor 1 is a T-type calcium channel inhibitor with little binding affinity to dopamine D2 receptors. Cav 3.2 inhibitor 1 can be used for the research of somatic and visceral pain[1].

IC50 & Target

Cav 3.2[1]

In Vitro

Cav 3.2 inhibitor 1 (compound 3a, 0.3 μM) inhibits Cav3.2 activities by about 50% in Cav3.2-transfected HEK293 cells[1].
Cav 3.2 inhibitor 1 (1 and 10 μM) displays little binding affinity to D2 receptors[1].
Cav 3.2 inhibitor 1 (0.01-1 μM) inhibits T-currents in Cav3.1-expressing HEK293 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cav 3.2 inhibitor 1 (compound 3a, 10 mg/kg, i.p.) suppresses Cav3.2-dependent somatic and visceral pain in mice[1].
Cav 3.2 inhibitor 1 (8 nmol/mouse, i.c.v.) has no effect on long-lasting catalepsy in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Colonic pain and referred hyperalgesia mice induced by intracolonic (i.col.) administration of Na2S at 5 nmol/mouse[1].
Dosage: 1-10 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Completely blocked the Na2S-induced colonic pain and referred hyperalgesia.
Molecular Weight

481.67

Formula

C32H39N3O

SMILES

O=C1N(CCCCC2=CC=CC=C2)C3=CC=CC=C3N1C4CCN(CCCCC5=CC=CC=C5)CC4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Cav 3.2 inhibitor 1
Cat. No.:
HY-151450
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