1. Apoptosis
  2. Apoptosis
  3. Anticancer agent 32

Anticancer agent 32 (compound 2g) is an anticancer agent. Anticancer agent 32 shows anticancer activities, affects cell cycle and induces cell apoptosis. Anticancer agent 32 can be used for the research of cancer.

For research use only. We do not sell to patients.

Anticancer agent 32 Chemical Structure

Anticancer agent 32 Chemical Structure

CAS No. : 2222930-76-7

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Anticancer agent 32 (compound 2g) is an anticancer agent. Anticancer agent 32 shows anticancer activities, affects cell cycle and induces cell apoptosis. Anticancer agent 32 can be used for the research of cancer[1].

IC50 & Target

IC50: 17.2 μM (MGC-803), 12.3 μM (HeLa), 40.6 μM (NCI-H460), 46.8 μM (HepG2), 95.4 μM (SMMC-7721), 8.9 μM (T-24), 86.8 μM (HL-7702)[1]

In Vitro

Anticancer agent 32 (2.5-40 μM; 48 h) shows cytotoxic activities to cancer cell lines[1].
Anticancer agent 32 (0-16 μM; 24 h) affects cell cycle, induces cell apoptosis, increases intracellular levels of Ca2+ and ROS[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: MGC-803, HeLa, NCI-H460, HepG2, SMMC-7721, T-24 and HL-7702 cell lines
Concentration: 2.5, 5, 10, 20 and 40 μM
Incubation Time: 48 hours
Result: Inhibited cell growth with IC50 values of 17.2, 12.3, 40.6, 46.8, 95.4, 8.9 and 86.8 μM for MGC-803, HeLa, NCI-H460, HepG2, SMMC-7721, T-24 and HL-7702 cells, respectively.

Cell Cycle Analysis[1]

Cell Line: MGC-803 and T-24 cell lines
Concentration: 0, 8 and 12 μM
Incubation Time: 24 hours
Result: Significantly induced cell cycle arrest at the G2/M phase in T-24 cells.

Western Blot Analysis[1]

Cell Line: MGC-803 and T-24 cell lines
Concentration: 4, 8 and 12 μM
Incubation Time: 24 hours
Result: Decreased expression level of cyclin B1.

Apoptosis Analysis[1]

Cell Line: MGC-803 and T-24 cell lines
Concentration: 0, 4, 8 and 16 μM
Incubation Time: 24 hours
Result: Induced cell apoptosis of T-24 cells from 8.21 to 32.91% after treatment by increasing levels of caspase-3 and caspase-9 in T-24 cells.
Molecular Weight

433.45

Formula

C24H21F2N5O

CAS No.
SMILES

CC1=CC(C)=CC(NC(NC2=CC=CC(CNC3=NC4=CC(F)=C(C=C4N=C3)F)=C2)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Anticancer agent 32 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Anticancer agent 32
Cat. No.:
HY-143303
Quantity:
MCE Japan Authorized Agent: