country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-182764A

Copy Link Print Information

CDK11-IN-1 hydrochloride

CDK11-IN-1 hydrochloride is an orally active cyclin-dependent kinase 11 (CDK11) inhibitor with an IC₅₀ of 4 nM, and it exhibits high selectivity against other kinases including CDK7 and CDK9. CDK11-IN-1 hydrochloride inhibits tumor growth in lung cancer xenograft models. CDK11-IN-1 hydrochloride can be used for lung cancer research.

For research use only. We do not sell to patients.

Formula: C₁₉H₂₁ClFN₅
Molecular Weight:373.85

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CDK11-IN-1 hydrochloride Chemical Structure

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

CDK11

4 nM (IC₅₀)

All CDK Isoforms :

In Vitro

CDK11-IN-1 (Compound 37) (72 h) hydrochloride inhibits the growth of KHOS osteosarcoma cells and LU99 lung cancer cells in CellTiter-Glo assays, with a GI₅₀ of 3.7 μM against the former and 0.40 μM against the latter^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CDK11-IN-1 (Compound 37) (10-100 mg/kg; p.o.; once/twice daily; 14 days) hydrochloride exhibits 30% tumour growth inhibition in LU99 lung cancer xenograft mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c nude mice (NU/JInv) (female, 7-8 weeks old)^[1]
Dosage:

10 mg/kg; 30 mg/kg; 100 mg/kg (once daily); 100 mg/kg (twice daily)
Administration:

p.o.; once daily; 14 days; p.o.; twice daily; 14 days
Result:

Showed no significant body weight loss or clinical signs across all dosing regimens.
Did not significantly inhibit tumour growth with once-daily dosing at 10, 30, and 100 mg/kg.
Achieved 30% tumour growth inhibition (TGI) on Day 14 with twice-daily dosing at 100 mg/kg.

Chemical Information

Molecular Weight 373.85
Formula C₁₉H₂₁ClFN₅
SMILES

F[C@H](CNC1)C[C@@H]1NC2=NC(C(C=C3)=CN3C4=CC=CC=C4)=CC=N2.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mak FS, et al. In Silico-Enabled Discovery and Development of Potent and Selective CDK11 Inhibitors. ChemMedChem. 2026;21(6):e202500882. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote