CDK11-IN-1 hydrochloride

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CDK11-IN-1 hydrochloride is a potent, highly selective, and orally active CDK11 inhibitor with an IC₅₀ of 4 nM, showing 32.5-fold and 2700-fold selectivity over CDK7 and CDK9, respectively. CDK11-IN-1 hydrochloride binds competitively to the ATP-binding pocket of CDK11 and forms a hydrogen bond with the hinge region residue Val163. It inhibits tumor cell proliferation and exhibits antitumor activity in lung cancer xenograft models. CDK11-IN-1 hydrochloride can be used for studies on the pathophysiology of CDK11-mediated tumors, as well as research on malignant tumors such as lung cancer.

For research use only. We do not sell to patients.

CDK11-IN-1 hydrochloride Chemical Structure

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•Related Small Molecules:

•Related Proteins:

View All CDK Isoform Specific Products:

View All Isoforms

CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

CDK11

4 nM (IC₅₀)

In Vitro

CDK11-IN-1 (compound 37) (5 nM-100 μM；72 h) hydrochloride , inhibits KHOS and LU99 cells in CellTiter-Glo viability assays, with the GI₅₀ values are 3.7 μM for KHOS cells and 0.40 μM for LU99 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	KHOS, LU99
Concentration:	5 nM, 15 nM, 45 nM, 135 nM, 405 nM, 1.215 μM, 3.645 μM, 10.935 μM, 32.805 μM, 100 μM (3-fold serial dilution)
Incubation Time:	72 h
Result:	Inhibited cell proliferation, with GI₅₀ values of 3.7 μM in KHOS cells and 0.40 μM in LU99 cells.

In Vivo

CDK11-IN-1 (compound 37) (50-200 mg/kg; p.o.; once daily; 14 days) hydrochloride is well tolerated in female BALB/c nude mouse models, with no obvious toxicity or significant body weight loss^[1].
CDK11-IN-1 (200 mg/kg; p.o.; single administration; 8 h post-administration) hydrochloride exhibits an intratumoral AUC_0-lastof 47074 ng・h/g and a C_maxof 7311 ng/g, with significantly higher tumor exposure levels than those in plasma in the LU99 lung cancer xenograft BALB/c nude mouse model^[1].
CDK11-IN-1 (10, 30, 100 mg/kg; p.o.; twice daily; 14 days) hydrochloride achieves 30% tumor growth inhibition in the LU99 lung cancer xenograft BALB/c nude mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female BALB/c nude mice (7-8 weeks old, unspecified weight) bearing LU99 lung cancer xenografts, anti-tumor efficacy model^[1]
Dosage:	10 mg/kg, 30 mg/kg, 100 mg/kg (once daily for 14 days); 100 mg/kg
Administration:	1) once daily for 14 days 2) twice daily for 14 days
Result:	Once-daily dosing at 10, 30 or 100 mg/kg did not significantly inhibit tumor growth, while twice-daily dosing at 100 mg/kg produced 30% tumor growth inhibition (TGI); all treatments were well tolerated with no significant body weight loss.

Molecular Weight

373.85

Formula

C₁₉H₂₁ClFN₅

SMILES

F[C@H](CNC1)C[C@@H]1NC2=NC(C(C=C3)=CN3C4=CC=CC=C4)=CC=N2.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mak FS, et al. In Silico-Enabled Discovery and Development of Potent and Selective CDK11 Inhibitors. ChemMedChem. 2026;21(6):e202500882.