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Cat. No.: HY-148110

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FAK-IN-8

FAK-IN-8 (compound 5h) is a FAK inhibitor (IC₅₀=5.32 µM). FAK-IN-8 has good anti-proliferative activity and can be used in cancer research.

For research use only. We do not sell to patients.

CAS No.: 1374959-91-7
Formula: C₁₅H₉Cl₂N₃O₂S
Molecular Weight:366.22

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

FAK-IN-8 Chemical Structure

CAS No.: 1374959-91-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

FAK-IN-8 (compound 5h) is a FAK inhibitor (IC₅₀=5.32 µM). FAK-IN-8 has good anti-proliferative activity and can be used in cancer research^[1].

IC₅₀ & Target^[1]

FAK

5.32 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
B16-F10	IC₅₀	0.31 μM Compound: 5h	Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay	[PMID: 22503364]
MCF7	IC₅₀	0.45 μM Compound: 5h	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 22503364]

In Vitro

FAK-IN-8 (0-10 µM; 48 h) inhibits MCF-7 and B16-F10 cells proliferation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

MCF-7 and B16-F10 cells
Concentration:

0-10 µM
Incubation Time:

48 h
Result:

Exhibited anti-proliferative activity against MCF-7 and B16-F10 cells with IC₅₀ values of 3.57 and 3.52 µM, respectively.

Chemical Information

CAS No. 1374959-91-7
Molecular Weight 366.22
Formula C₁₅H₉Cl₂N₃O₂S
SMILES

O=C(NC1=NN=C(C2=CC=C(Cl)C=C2)S1)C3=CC(Cl)=CC=C3O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang XH, et al. Synthesis, biological evaluation, and molecular docking studies of 1,3,4-thiadiazol-2-amide derivatives as novel anticancer agents. Bioorg Med Chem. 2012 May 1;20(9):2789-95. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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