2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. T-Type calcium channel inhibitor 2

T-Type calcium channel inhibitor 2 (compound 6g) is a potent T-type calcium channel inhibitor with IC50s of 31.0, 83.1, 69.3 µM for Cav3.1 (α1G), Cav3.2 (α1H), Cav3.3 (α1I) (α1H), respectively. T-Type calcium channel inhibitor 2 shows cytotoxicity for A549, HCT-116 cells with IC50s of 5.0, 6.4 µM, respectively.

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T-Type calcium channel inhibitor 2

T-Type calcium channel inhibitor 2 構造式

CAS 番号 : 2771965-57-0

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T-Type calcium channel inhibitor 2 関連抗体

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製品説明

T-Type calcium channel inhibitor 2 (compound 6g) is a potent T-type calcium channel inhibitor with IC50s of 31.0, 83.1, 69.3 µM for Cav3.1 (α1G), Cav3.2 (α1H), Cav3.3 (α1I) (α1H), respectively. T-Type calcium channel inhibitor 2 shows cytotoxicity for A549, HCT-116 cells with IC50s of 5.0, 6.4 µM, respectively[1].

IC50 & Target[1]

CaV3.1

31.0 μM (IC50)

Cav3.2

83.1 μM (IC50)

CaV3.3

69.3 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
A549 IC50
5 μM
Compound: 6g
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32327350]
HCT-116 IC50
6.4 μM
Compound: 6g
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32327350]
分子量

594.78

分子式

C36H39FN4OS
CAS 番号
SMILES

CN(CCCCCSC1=NC2=CC=CC=C2C(N1C3=CC=C(C=C3)C4=CC=CC=C4)CC(NCC5=CC=C(C=C5)F)=O)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
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参考文献
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T-Type calcium channel inhibitor 2 Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

T-Type calcium channel inhibitor 22771965-57-0Calcium ChannelCa2+ channelsCa channelsanti-neoplasticA549HCT-116 cellscytotoxicity2-thio-3,4-dihydroquinazolineInhibitorinhibitorinhibit

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製品名:
T-Type calcium channel inhibitor 2
製品番号:
HY-147708
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