c-Met-IN-31
c-Met-IN-31 is a c-Met inhibitor with an IC50 value of 0.021 μM. c-Met-IN-31 also inhibits VEGFR-2 and EGFR activities, with IC50 values of 0.32 μM and 9.3 μM, respectively. c-Met-IN-31 inhibits cancer cell proliferation. c-Met-IN-31 suppresses neovascularization in the chick chorioallantoic membrane (CAM) assay, exhibiting in vivo anti-angiogenic activity. c-Met-IN-31 can be used in research related to breast cancer and lung cancer.
For research use only. We do not sell to patients.
- Formula: C31H26N6O4S
- Molecular Weight:578.64
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
c-Met 0.021 μM (IC50) |
VEGFR2 0.32 μM (IC50) |
EGFR 9.3 μM (IC50) |
In Vitro
c-Met-IN-31 (compound 18) exhibits inhibitory activity against A549 and MCF7 cells after 72 h, with IC50 values of 1.98 μM and 0.74 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 578.64
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Formula C31H26N6O4S
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SMILES
O=C(NC1=CC=CN=C1)NC2=CC=C(COC3=CC=C4N=C(NC5=CC=NC6=CC(OC)=C(OC)C=C56)SC4=C3)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
c-Met-IN-31 Related Classifications
HY-181776 Related Classifications
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