2. Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. c-Met/HGFR VEGFR EGFR
  4. c-Met-IN-31

c-Met-IN-31 is a c-Met inhibitor with an IC50 value of 0.021 μM. c-Met-IN-31 also inhibits VEGFR-2 and EGFR activities, with IC50 values ​​of 0.32 μM and 9.3 μM, respectively. c-Met-IN-31 inhibits cancer cell proliferation. c-Met-IN-31 suppresses neovascularization in the chick chorioallantoic membrane (CAM) assay, exhibiting in vivo anti-angiogenic activity. c-Met-IN-31 can be used in research related to breast cancer and lung cancer.

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c-Met-IN-31

c-Met-IN-31 Chemische Struktur

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c-Met-IN-31 Related Antibodies

Top Publications Citing Use of Products

Alle VEGFR Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

Alle EGFR Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Beschreibung

c-Met-IN-31 is a c-Met inhibitor with an IC50 value of 0.021 μM. c-Met-IN-31 also inhibits VEGFR-2 and EGFR activities, with IC50 values ​​of 0.32 μM and 9.3 μM, respectively. c-Met-IN-31 inhibits cancer cell proliferation. c-Met-IN-31 suppresses neovascularization in the chick chorioallantoic membrane (CAM) assay, exhibiting in vivo anti-angiogenic activity. c-Met-IN-31 can be used in research related to breast cancer and lung cancer[1].

IC50 & Target[1]

c-Met

0.021 μM (IC50)

VEGFR2

0.32 μM (IC50)

EGFR

9.3 μM (IC50)

In Vitro

c-Met-IN-31 (compound 18) exhibits inhibitory activity against A549 and MCF7 cells after 72 h, with IC50 values of 1.98 μM and 0.74 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

c-Met-IN-31 Related Antibodies
In Vivo

c-Met-IN-31 (administered locally; single dose; 24 h) inhibits neovascularization in the chick chorioallantoic membrane (CAM) assay, exhibiting in vivo anti-angiogenic activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molekulargewicht

578.64

Formel

C31H26N6O4S
SMILES

O=C(NC1=CC=CN=C1)NC2=CC=C(COC3=CC=C4N=C(NC5=CC=NC6=CC(OC)=C(OC)C=C56)SC4=C3)C=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
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c-Met-IN-31 Related Classifications

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Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

c-Met-IN-31c-Met/HGFRVEGFREGFRVascular endothelial growth factor receptorEpidermal growth factor receptorErbB-1HER1A549 cellsMCF7 cellsVEGFR-2/c-Met/EGFR inhibitorbreast cancerlung cancerInhibitorinhibitorinhibit

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