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  2. Bacterial
  3. Antitubercular agent-32

Antitubercular agent-32 

Cat. No.: HY-151340
Handling Instructions

Antitubercular agent-32 is a derivate of Benzothiazinone (HY-13579A), inhibits M. tuberculosis, and shows improved metabolic stability and enhanced water solubility. Antitubercular agent-32 exerts antitubercular effect by targeting decaprenylphosphoryl-β-D-ribose 2’-oxidase (DprE1, IC50=3.9 μM).

For research use only. We do not sell to patients.

Antitubercular agent-32 Chemical Structure

Antitubercular agent-32 Chemical Structure

CAS No. : 2498762-42-6

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Description

Antitubercular agent-32 is a derivate of Benzothiazinone (HY-13579A), inhibits M. tuberculosis, and shows improved metabolic stability and enhanced water solubility. Antitubercular agent-32 exerts antitubercular effect by targeting decaprenylphosphoryl-β-D-ribose 2’-oxidase (DprE1, IC50=3.9 μM)[1].

In Vitro

Antitubercular agent-32 (compound 8) (0-7.5 mg/mL; 48 h) shows low cytotoxicity and inhibits M. tuberculosis H37Rv with the minimum inhibition concentration (MIC) of 40 nM[1].
Antitubercular agent-32 (0-20 μM) inhibits decaprenylphosphoryl-β-D-ribose 2’-oxidase (DprE1, 0.5 μM), an enzyme essential for the biosynthesis of mycobacterial cell wall, with an IC50 value of 3.9 μM[1].
Antitubercular agent-32 (1 μM; 10 min) exhibits metabolic stability in the liver microsomal metabolic of both human (HLM) and mouse (MLM), with fast clearance rates of 77 mL/min/kg (HLM) and 163 mL/min/kg (MLM), respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: HepG2 cells
Concentration: 0, 15, 30, 75, 150, 300, 750, 1500, 3000, and 7500 ng/mL
Incubation Time: 48 hours
Result: There were no significantly growth inhibitions of HepG2 cells.
Molecular Weight

492.61

Formula

C22H28N4O5S2

CAS No.
SMILES

CS(=O)(C(C=C12)=CC([N+]([O-])=O)=C1SC(N(CCN3CC4CCCCC4)CC53CC5)=NC2=O)=O

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Antitubercular agent-32
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HY-151340
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