1. GPCR/G Protein
  2. GPR40
  3. TUG-424

TUG-424 

Cat. No.: HY-14363 Purity: >98.0%
Handling Instructions

TUG-424 is a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with an EC50 of 32 nM. TUG-424 significantly increases glucose-stimulated insulin secretion at 100 nM. TUG-424 may serve to explore the role of FFA1 in metabolic diseases such as diabetes or obesity.

For research use only. We do not sell to patients.

TUG-424 Chemical Structure

TUG-424 Chemical Structure

CAS No. : 1082058-99-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 422 In-stock
Estimated Time of Arrival: December 31
1 mg USD 145 In-stock
Estimated Time of Arrival: December 31
5 mg USD 430 Get quote
10 mg   Get quote  
50 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

TUG-424 is a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with an EC50 of 32 nM. TUG-424 significantly increases glucose-stimulated insulin secretion at 100 nM. TUG-424 may serve to explore the role of FFA1 in metabolic diseases such as diabetes or obesity[1].

IC50 & Target

EC50: 32 nM (FFA1/GPR40)[1]

In Vitro

Increasing concentrations (100 nM to 10 µM) of TUG-424 enhances glucose-stimulated insulin secretion significantly already at 100 nM and with a maximal effect at 3 µM. The approximately 2-fold stimulation of secretion by TUG-424 in the presence of 12 mM glucose is comparable to that induced by palmitate in the presence of the same glucose concentration. Basal insulin secretion at 2.8 mM glucose is slightly but significantly reduces by TUG-424[1].

Molecular Weight

264.32

Formula

C₁₈H₁₆O₂

CAS No.

1082058-99-8

SMILES

OC(CCC(C=C1)=CC=C1C#CC2=C(C)C=CC=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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Keywords:

TUG-424TUG424TUG 424GPR40Free fatty acid receptor 1FFAR1FFA1G-protein-coupled receptor 40selectiveglucosediabetesobesityinsulinsecretionGSISInhibitorinhibitorinhibit

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Product name:
TUG-424
Cat. No.:
HY-14363
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