1. Cell Cycle/DNA Damage Cytoskeleton
  2. Microtubule/Tubulin
  3. Microtubule inhibitor 4

Microtubule inhibitor 4 (compound 2) is a potent microtubule inhibitor. Microtubule inhibitor 4 shows cytotoxicity with IC50s of 4.0, 3.2, 2.1 nM for NCI-H460, BxPC-3, HT-29 cells, respectively. Microtubule inhibitor 4 shows the inhibition of tubulin polymerization.

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Microtubule inhibitor 4 Chemical Structure

Microtubule inhibitor 4 Chemical Structure

CAS No. : 2411962-64-4

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Description

Microtubule inhibitor 4 (compound 2) is a potent microtubule inhibitor. Microtubule inhibitor 4 shows cytotoxicity with IC50s of 4.0, 3.2, 2.1 nM for NCI-H460, BxPC-3, HT-29 cells, respectively. Microtubule inhibitor 4 shows the inhibition of tubulin polymerization[1].

Molecular Weight

446.47

Formula

C25H23FN4O3

CAS No.
SMILES

CC(C)(C1=C(N=CN1)/C=C2NC(/C(NC\2=O)=C/C3=CC(OC4=CC=C(C=C4)F)=CC=C3)=O)C

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Microtubule inhibitor 4 Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Microtubule inhibitor 4
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HY-147725
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