TP53RK Antibody (YA8357)

Cat. No.: HY-P88673: Ficha de datos User Guide for Antibodies
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TP53RK Antibody (YA8357) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TP53RK.

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Tamaño		Stock
50 μL		Obtener un presupuesto
100 μL		Obtener un presupuesto

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn

Descripciòn

TP53RK Antibody (YA8357) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TP53RK.

Host

Mouse

Clonality

Monoclonal

Peso molecular

Predicted band size: 28 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q96S44

Immunogen

Full length human recombinant protein of human TP53RK produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

Sensitivity	Endogenous	Pureza	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806)

Subcellular Localization：Cytoplasm,Nucleus

Expression：
Tissue_Specificity: Highly expressed in testis. Weakly expressed in heart kidney and spleen

Isoforms & Post-Translational Modification：Q96S44: 253 amino acids, molecular weight 28160 Da.

Subunit：Component of the EKC/KEOPS complex composed of at least GON7, TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes

Synonyms

BUD32; C20orf64; dJ101A2; Nori-2; Nori-2p; PRPK

Documentación

User Guide for Antibodies (1077 KB)