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Cat. No.: HY-163474

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MAO-B-IN-32

MAO-B-IN-32 is an inhibitor of MAO-B (IC₅₀ = 16 nM).MAO-B-IN-32 increases dopamine concentration in the brain by inhibiting MAO-B activity.

For research use only. We do not sell to patients.

Formula: C₂₀H₁₉FO₄
Molecular Weight:342.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

MAO-B-IN-32 Chemical Structure

Price

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Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

MAO-B-IN-32 is an inhibitor of MAO-B (IC₅₀ = 16 nM).MAO-B-IN-32 increases dopamine concentration in the brain by inhibiting MAO-B activity^[1].

IC₅₀ & Target

MAO-B

16 nM (IC₅₀)

All Monoamine Oxidase Isoforms :

MAO-A
MAO-B

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	GI₅₀	10.2 μM Compound: 9f	Growth inhibition of HEK293 cells incubated for 72 hrs by MTT assay Growth inhibition of HEK293 cells incubated for 72 hrs by MTT assay	[PMID: 38746894]
MDA-MB-231	GI₅₀	>20 μM Compound: 9f	Growth inhibition of human MDA-MB-231 cells incubated for 72 hrs by MTT assay Growth inhibition of human MDA-MB-231 cells incubated for 72 hrs by MTT assay	[PMID: 38746894]
SH-SY5Y	GI₅₀	>20 μM Compound: 9f	Growth inhibition of human SH-SY5Y cells incubated for 72 hrs by MTT assay Growth inhibition of human SH-SY5Y cells incubated for 72 hrs by MTT assay	[PMID: 38746894]

Chemical Information

Molecular Weight 342.36
Formula C₂₀H₁₉FO₄
SMILES

O=C1C=C(C2=CC=C(OCC(C)C)C=C2)OC3=C1C(F)=CC(OC)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jorge I. et al. Synthesis and Monoamine Oxidase Inhibitory Activity of Halogenated Flavones. ACS Medicinal Chemistry Letters Article ASAP

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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