PD-1/PD-L1-IN-32
PD-1/PD-L1-IN-32 (compound A56) is a potent PD-1/PD-L1 inhibitor (IC50=2.4 nM), with anticancer activity. PD-1/PD-L1-IN-32 significantly inhibits tumor growth in hPD-L1 MC38 humanized mouse model, without obvious toxicity against mouse normal ability.
For research use only. We do not sell to patients.
- CAS No.: 2765535-21-3
- Formula: C29H25ClFN3O3
- Molecular Weight:517.98
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
IC50: 2.4 nM (PD-1/PD-L1)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MC-38 | IC50 |
>8 μM
Compound: A56
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Antitumor activity against mouse MC38 cells expressing human PD-L1 protein assessed as reduction in cell viability measured after 48 hrs by CCK-8 assay
Antitumor activity against mouse MC38 cells expressing human PD-L1 protein assessed as reduction in cell viability measured after 48 hrs by CCK-8 assay
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[PMID: 37496104] |
Pharmacokinetic Analysis of PD-1/PD-L1-IN-32 (compound A56) in SD Rat Model[1]
| Route | Dose (mg/kg) | AUC(0-t) (μg/L·h) | AUC(0-∞) (μg/L·h) | Cmax (μg/L) | Tmax (h) | t1/2 (h) | V1 (L/kg) | CL (L/h/kg) | F (%) |
| iv | 8 | 11487.46 | 13353.19 | 6227.50 | 0.08 | 0.99 | 1.09 | 0.60 | |
| ig | 40 | 63579.08 | 65527.75 | 21504.90 | 1.75 | 1.72 | 1.80 | 0.62 | 114.09 |
| ip | 10 | 9729.84 | 10504.11 | 4156.54 | 0.88 | 2.43 | 2.94 | 1.21 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2765535-21-3
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Molecular Weight 517.98
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Formula C29H25ClFN3O3
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SMILES
N#CC1=CC(COC2=C(C=CC(OCC3=C(C(C4=CC=CC=C4F)=CC=C3)Cl)=C2)CNCCO)=CN=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)