2. Metabolic Enzyme/Protease
  3. PI5P4K
  4. PI5P4Ks-IN-2

PI5P4Ks-IN-2 is a inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ). PI5P4Ks-IN-2 targets to PI5P4K isoforms with pIC50 values of <4.3 (PI5P4Kα), <4.6 (PI5P4Kβ), 6.2 (PI5P4Kγ), 0.32 (PI5P4Kγ+), respectively.

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PI5P4Ks-IN-2 Chemical Structure

PI5P4Ks-IN-2 Chemical Structure

CAS No. : 2766854-03-7

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 1242 In-stock
Solution
10 mM * 1 mL in DMSO USD 1242 In-stock
Solid
1 mg USD 316 In-stock
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Based on 1 publication(s) in Google Scholar

PI5P4Ks-IN-2 Related Antibodies

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  • Purity & Documentation

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Description

PI5P4Ks-IN-2 is a inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ). PI5P4Ks-IN-2 targets to PI5P4K isoforms with pIC50 values of <4.3 (PI5P4Kα), <4.6 (PI5P4Kβ), 6.2 (PI5P4Kγ), 0.32 (PI5P4Kγ+), respectively[1].

IC50 & Target

PI5P4K[1]
In Vitro

PI5P4Ks-IN-2 (compound 40) (10 μM) shows selectivity against a panel of 140 protein kinases and 15 lipid kinases, and binds to PI5P4Kγ-WT (Ki=68 nM) or PI5P4Kβ (Ki >30,000 nM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PI5P4Ks-IN-2 Related Antibodies
Molecular Weight

357.45

Formula

C22H23N5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CN1C=CC2=C1C(NCC3=NC=CC=C3)=NC(C4=CC=CC=C4C(C)C)=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (349.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7976 mL 13.9880 mL 27.9759 mL
5 mM 0.5595 mL 2.7976 mL 5.5952 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.78%

COA (253 KB) HNMR (264 KB) LCMS (128 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7976 mL 13.9880 mL 27.9759 mL 69.9398 mL
5 mM 0.5595 mL 2.7976 mL 5.5952 mL 13.9880 mL
10 mM 0.2798 mL 1.3988 mL 2.7976 mL 6.9940 mL
15 mM 0.1865 mL 0.9325 mL 1.8651 mL 4.6627 mL
20 mM 0.1399 mL 0.6994 mL 1.3988 mL 3.4970 mL
25 mM 0.1119 mL 0.5595 mL 1.1190 mL 2.7976 mL
30 mM 0.0933 mL 0.4663 mL 0.9325 mL 2.3313 mL
40 mM 0.0699 mL 0.3497 mL 0.6994 mL 1.7485 mL
50 mM 0.0560 mL 0.2798 mL 0.5595 mL 1.3988 mL
60 mM 0.0466 mL 0.2331 mL 0.4663 mL 1.1657 mL
80 mM 0.0350 mL 0.1748 mL 0.3497 mL 0.8742 mL
100 mM 0.0280 mL 0.1399 mL 0.2798 mL 0.6994 mL
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PI5P4Ks-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI5P4Ks-IN-22766854-03-7PI5P4KPIP4KPI5P4KαPI5P4KβPI5P4KγPI5P4Kγ+phosphatidylinositol 5-phosphate 4-kinaseInhibitorinhibitorinhibit

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