MSNBA
Based on 1 publication(s) in Google Scholar
MSNBA is a potent and selective GLUT5 fructose transport inhibitor with an IC50 of 0.10 mM. MSNBA does not affect the transport activity of human GLUT1, GLUT2, GLUT3, GLUT4 or bacterial GlcPSe. MSNBA competitively inhibits GLUT5 fructose uptake with a Ki of 3.2 μM in MCF7 cells. MSNBA can be used for the study of cancer or diabetes.
For research use only. We do not sell to patients.
- Purity: 97.39%
- CAS No.: 852702-51-3
- Formula: C14H12N2O6S
- Molecular Weight:336.32
-
Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Membrane Transporter/Ion Channel Compound Library
HY-L011
-
Anti-Cancer Compound Library
HY-L025
-
Anti-diabetic Compound Library
HY-L040
-
Antibacterial Compound Library
HY-L049
-
Glycolysis Compound Library
HY-L058
-
Glutamine Metabolism Compound Library
HY-L064
-
Anti-Cancer Metabolism Compound Library
HY-L083
-
Glucose Metabolism Compound Library
HY-L092
-
Metabolic Enzyme Compound Library
HY-L146
-
Membrane Protein-targeted Compound Library
HY-L149
-
Membrane Receptor-targeted Compound Library
HY-L150
-
Highly Selective Inhibitors Library
HY-L158
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
-
High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) MSNBA
More
Biological Activity
In the presence of 10 mM fructose, MSNBA inhibits fructose uptake in MCF7 cells with an IC50 of 5.8 μM[1].
MSNBA (1-1000 µM; 24 h) significantly decreases the viability of colon cancer cells, while barely affects the viability of normal colon epithelium cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:The colon cancer cell line HT-29 and normal colon epithelium CCD 841 CoN cells
-
Concentration:1 µM, 10 µM, 100 µM, 1000 µM
-
Incubation Time:24 h
-
Result:Significantly decreased cell viability of HT-29 cells (51% decrease with 10 µM and 55% with 1 µM MSNBA), while CoN cells were only slightly affected by these concentrations.
Chemical Information
-
CAS No. 852702-51-3
-
Appearance Solid
-
Molecular Weight 336.32
-
Formula C14H12N2O6S
-
Color Brown to dark brown
-
SMILES
O=[N+](C1=CC(S(=O)(C)=O)=CC=C1NC2=CC3=C(OCO3)C=C2)[O-]
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Biochem Biophys Res Commun
2026 Mar 12:804:153358. PMID: 41619507
Solvent & Solubility
DMSO : 100 mg/mL (297.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (276 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. George Thompson AM, et al. Discovery of a specific inhibitor of human GLUT5 by virtual screening and in vitro transport evaluation. Sci Rep. 2016 Apr 14;6:24240. [Content Brief]
[2]. Włodarczyk J, et al. Blockade of fructose transporter protein GLUT5 inhibits proliferation of colon cancer cells: proof of concept for a new class of anti-tumor therapeutics. Pharmacol Rep. 2021 Jun;73(3):939-945. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9734 mL | 14.8668 mL | 29.7336 mL | 74.3340 mL |
| 5 mM | 0.5947 mL | 2.9734 mL | 5.9467 mL | 14.8668 mL | |
| 10 mM | 0.2973 mL | 1.4867 mL | 2.9734 mL | 7.4334 mL | |
| 15 mM | 0.1982 mL | 0.9911 mL | 1.9822 mL | 4.9556 mL | |
| 20 mM | 0.1487 mL | 0.7433 mL | 1.4867 mL | 3.7167 mL | |
| 25 mM | 0.1189 mL | 0.5947 mL | 1.1893 mL | 2.9734 mL | |
| 30 mM | 0.0991 mL | 0.4956 mL | 0.9911 mL | 2.4778 mL | |
| 40 mM | 0.0743 mL | 0.3717 mL | 0.7433 mL | 1.8583 mL | |
| 50 mM | 0.0595 mL | 0.2973 mL | 0.5947 mL | 1.4867 mL | |
| 60 mM | 0.0496 mL | 0.2478 mL | 0.4956 mL | 1.2389 mL | |
| 80 mM | 0.0372 mL | 0.1858 mL | 0.3717 mL | 0.9292 mL | |
| 100 mM | 0.0297 mL | 0.1487 mL | 0.2973 mL | 0.7433 mL |
Powered by Bioz