RQ-00311651
RQ-00311651 is a T-type calcium channel blocker that specifically targets the Cav3.2 isoform with a role in neuropathic and visceral pain. RQ-00311651 significantly inhibits T currents in HEK293 cells expressing human Cav3.1 or Cav3.2. RQ-00311651 also inhibited high potassium-induced calcium signaling. RQ-00311651 also inhibits antiallergic properties in rats and mice with neuropathic pain induced by spinal nerve injury or Paclitaxel (HY-B0015). Oral and intraperitoneal injection (10-20 mg/kg) inhibits Cerulein (HY-A0190)-induced acute pancreatitis and cyclophosphamide-induced cystitis in mice.
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- CAS. Nr.: 1257116-00-9
- Formel: C19H18F3N5O2
- Molecular Weight:405.37
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Biologische Aktivität
Beschreibung
IC50 & Target
Cav3.1; Cav3.2[1]
Chemical Information
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CAS. Nr. 1257116-00-9
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Molecular Weight 405.37
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Formel C19H18F3N5O2
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SMILES
O=C(N[C@H](C)C1=NC=C(N=C1)OCC(F)(F)F)[C@@H]2[C@H](C2)C3=NC4=CC=CC=C4N3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
RQ-00311651 Related Classifications
HY-118030 Related Classifications
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