2. Neuronal Signaling
  3. Beta-secretase
  4. BACE1-IN-12

BACE1-IN-12 (compound 7g) is a potent and BBB-penetrated BACE1 inhibitor, with an IC50 of 8.9 µM. BACE1-IN-12 shows selective BuChE (butyrylcholinesterase) inhibitory activity with an IC50 of 3.2 µM. BACE1-IN-12 shows effective antioxidant effect with an IC50 of 10.2 μM (DPPH). BACE1-IN-12 might be served as a potential anti-Alzheimer agent.

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BACE1-IN-12 Chemical Structure

BACE1-IN-12 Chemical Structure

CAS No. : 2479315-19-8

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BACE1-IN-12 Related Antibodies

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Description

BACE1-IN-12 (compound 7g) is a potent and BBB-penetrated BACE1 inhibitor, with an IC50 of 8.9 µM. BACE1-IN-12 shows selective BuChE (butyrylcholinesterase) inhibitory activity with an IC50 of 3.2 µM. BACE1-IN-12 shows effective antioxidant effect with an IC50 of 10.2 μM (DPPH). BACE1-IN-12 might be served as a potential anti-Alzheimer agent[1].

IC50 & Target

IC50: 8.9 ± 0.20 µM (BACE1), 3.2 ± 0.2 µM (BuChE)[1]
Molecular Weight

547.48

Formula

C29H28Cl2N6O
CAS No.
SMILES

ClC1=CC=C(CN2N=NC(COC3=CC=C(C4=C(NC5CCCCC5)N6C=CC=CC6=N4)C=C3)=C2)C=C1Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BACE1-IN-12 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BACE1-IN-122479315-19-8Beta-secretaseBACEβ-SecretaseAlzheimer’s diseaseADImidazopyridineBACE1 inhibitor1,2,3-triazoleneurodegenerative disorderantioxidant activitycholinesterase inhibitorInhibitorinhibitorinhibit

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