BACE1-IN-12
BACE1-IN-12 (compound 7g) is a potent and BBB-penetrated BACE1 inhibitor, with an IC50 of 8.9 µM. BACE1-IN-12 shows selective BuChE (butyrylcholinesterase) inhibitory activity with an IC50 of 3.2 µM. BACE1-IN-12 shows effective antioxidant effect with an IC50 of 10.2 μM (DPPH). BACE1-IN-12 might be served as a potential anti-Alzheimer agent.
For research use only. We do not sell to patients.
- CAS No.: 2479315-19-8
- Formula: C29H28Cl2N6O
- Molecular Weight:547.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
IC50: 8.9 ± 0.20 µM (BACE1), 3.2 ± 0.2 µM (BuChE)[1]
Chemical Information
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CAS No. 2479315-19-8
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Molecular Weight 547.48
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Formula C29H28Cl2N6O
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SMILES
ClC1=CC=C(CN2N=NC(COC3=CC=C(C4=C(NC5CCCCC5)N6C=CC=CC6=N4)C=C3)=C2)C=C1Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)