2479315-19-8
Chemical Structure
BACE1-IN-12
- CAS No.: 2479315-19-8
- Formula:C29H28Cl2N6O
- Molecular Weight:547.48
IUPAC Name: 2,2-dimethyl-5-oxocyclohexane-1-carboxylic acid
InChIKey: HTDFECQCNJDZSQ-UHFFFAOYSA-N
SMILES: ClC1=CC=C(CN2N=NC(COC3=CC=C(C4=C(NC5CCCCC5)N6C=CC=CC6=N4)C=C3)=C2)C=C1Cl
Biological Activity: BACE1-IN-12 (compound 7g) is a potent and BBB-penetrated BACE1 inhibitor, with an IC50 of 8.9 µM. BACE1-IN-12 shows selective BuChE (butyrylcholinesterase) inhibitory activity with an IC50 of 3.2 µM. BACE1-IN-12 shows effective antioxidant effect with an IC50 of 10.2 μM (DPPH). BACE1-IN-12 might be served as a potential anti-Alzheimer agent[1].
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BACE1-IN-12 | BACE1-IN-12 (compound 7g) is a potent and BBB-penetrated BACE1 inhibitor, with an IC50 of 8.9 µM. BACE1-IN-12 shows selective BuChE (butyrylcholinesterase) inhibitory activity with an IC50 of 3.2 µM. BACE1-IN-12 shows effective antioxidant effect with an IC50 of 10.2 μM (DPPH). BACE1-IN-12 might be served as a potential anti-Alzheimer agent. | |||||||||||||||||||||
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Keywords
