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Cat. No.: HY-169111

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SHP2-IN-32

SHP2-IN-32 (compound C6) is an orally active, allosteric SHP2 inhibitor with an IC₅₀ value of 0.13 nM. SHP2-IN-32 exhibits antitumor activity.

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CAS No.: 3043685-80-6
화학식: C₂₉H₂₇ClN₆O₂S
분자량:559.08

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

SHP2-IN-32 Chemical Structure

CAS No.: 3043685-80-6

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

SHP2-IN-32 (compound C6) is an orally active, allosteric SHP2 inhibitor with an IC₅₀ value of 0.13 nM. SHP2-IN-32 exhibits antitumor activity^[1].

IC₅₀ & Target

IC50:0.13 nM (SHP2)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
MV4-11	IC₅₀	3.5 nM Compound: C6	Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK-8 assay	[PMID: 39303516]

Chemical Information

CAS No. 3043685-80-6
분자량 559.08
화학식 C₂₉H₂₇ClN₆O₂S
SMILES

N[C@@H]1C2=C(C=CC=C2)CC13CCN(C4=NC=C(SC5=C(Cl)C(NC(C6=C(O)C=CN=C6)=O)=CC=C5)N=C4)CC3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lv X, et al. Discovery of novel substituted pyridine carboxamide derivatives as potent allosteric SHP2 inhibitors. Eur J Med Chem. 2024 Sep 5;279:116830. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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