5-HT6/5-HT2A receptor ligand-2
5-HT6/5-HT2A receptor ligand-2 (compound 42) is a brain-penetrant dual 5-HT6/5-HT2A receptor antagonist, with a Ki of 25 nM and 32 nM, respectively. 5-HT6/5-HT2A receptor ligand-2 shows pro-cognitive properties.
For research use only. We do not sell to patients.
- CAS No.: 2411088-16-7
- Formula: C20H18FN3O2
- Molecular Weight:351.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All 5-HT Receptor Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
5-HT2A Receptor |
5-HT6 Receptor |
5-HT6 Receptor 25 nM (Ki) |
5-HT2A Receptor 32 nM (Ki) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
5.14 μM
Compound: 42; PKSN-279
|
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by presto-blue assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by presto-blue assay
|
[PMID: 31734022] |
| HepG2 | IC50 |
6.2 μM
Compound: 42; PKSN-279
|
Cytotoxicity against human HepG2 cells after 24 hrs by ToxiLight bioassay
Cytotoxicity against human HepG2 cells after 24 hrs by ToxiLight bioassay
|
[PMID: 31734022] |
Chemical Information
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CAS No. 2411088-16-7
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Molecular Weight 351.37
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Formula C20H18FN3O2
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SMILES
OC1=CC=C(C2=CC=C(CNCCC3=CNC4=NC=C(F)C=C43)O2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)