Aha1/Hsp90-IN-1
Aha1/Hsp90-IN-1 (Compound 17) is an Aha1/Hsp90 complex inhibitor. Aha1/Hsp90-IN-1 disrupts Aha1/Hsp90 interactions with an IC50 of 3.32 μM. Aha1/Hsp90-IN-1 inhibits tau aggregation.
For research use only. We do not sell to patients.
- CAS No.: 2768265-58-1
- Formula: C22H17F3N4O2
- Molecular Weight:426.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 3.32 μM (Aha1/Hsp90 interactions)[1]
Aha1/Hsp90-IN-1 (Compound 17) (10 μM; 24 h) disrupts the Aha1/Hsp90 complex without direct inhibition of Hsp90 protein folding activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y neuroblastoma cells and Her2 overexpressing SK-BR-3 breast cancer cells
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Concentration:10 μM
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Incubation Time:24 h
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Result:Exhibited the ability to disrupt interactions between Aha1 and Hsp90. Did not induce the degradation of Hsp90 client proteins Her2 (in SK-BR-3 cells), Cdk6, or pAktS473 (in SH SY5Y cells), nor do they induce the expression of Hsp70, a marker of the heat shock response.
Chemical Information
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CAS No. 2768265-58-1
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Molecular Weight 426.39
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Formula C22H17F3N4O2
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SMILES
COC1=CC(C2=C(C=CC(C3=NN=NN3C4=CC=C(C=C4)C(F)(F)F)=C2)OC)=CC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Aha1/Hsp90-IN-1 Related Classifications
HY-151337 Related Classifications
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