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Cat. No.: HY-179304

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CL-F-B1

CL-F-B1 is a PD-L1 PROTAC degrader, with a DC₅₀ of 2.32 μM. CL-F-B1 promotes the ubiquitination and degradation of PD-L1. CL-F-B1 can be used in the research of colon cancer.
(Pink: PD-1/PD-L1 ligand (HY-120647); Blue: Ligands for E3 Ligase and Cereblon ligand (HY-41547); Black: linker).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₅₄H₅₄N₆O₁₀
Masse moléculaire:947.04

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

CL-F-B1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

CL-F-B1 is a PD-L1 PROTAC degrader, with a DC₅₀ of 2.32 μM. CL-F-B1 promotes the ubiquitination and degradation of PD-L1. CL-F-B1 can be used in the research of colon cancer^[1]. (Pink: PD-1/PD-L1 ligand (HY-120647); Blue: Ligands for E3 Ligase and Cereblon ligand (HY-41547); Black: linker).

Voir tous les produits spécifiques à Isoform PROTACs :

Chemical Information

Masse moléculaire 947.04
Formule C₅₄H₅₄N₆O₁₀
SMILES

O=C1N(C(C2=C(C=CC=C21)N[C@@H]3CC[C@@H](NC([C@@H](CO)NCC4=C(C=C(C(C)=C4)OCC5=CC=CC(C6=CC=C7OCCOC7=C6)=C5C)OCC8=CC(C#N)=CC=C8)=O)CC3)=O)C9CCC(NC9=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Qi Q, et al. Rational Design of PROTAC Degraders and Their Spatiotemporal Controlled Delivery for Enhanced Tumor Penetration and PD-L1 Protein Degradation. J Med Chem. 2025 Nov 13;68(21):22665-22688. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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CL-F-B1

Voir tous les produits spécifiques à Isoform PROTACs

Activité biologique

Description

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

CL-F-B1 Related Classifications

HY-179304 Related Classifications

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