CD69 Antibody (YA4696)
(Synonyms: CD69; CLEC2C; Early activation antigen CD69; Activation inducer molecule; AIM; BL-AC/P26; C-type lectin domain family 2 member C; EA1; Early T-cell activation antigen p60; GP32/28; Leukocyte surface antigen Leu-23; MLR-3; CD antigen CD69; CD69 nanobody; )CD69 Antibody (YA4696) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD69.
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Host:
Mouse
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Application:
ELISA
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Reactivity :
Human
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Formulation:
Supplied in Phosphate-buffered solution.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|
| Dilution Ratio | 1:5000-100000 |
Product Details
Product Properties
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Appearance
Solution
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Formulation
Supplied in Phosphate-buffered solution.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD69 is a transmembrane protein primarily expressed on mucosa-resident T cells, playing a crucial role in immune cell homeostasis. Following activation by various stimuli-such as antigen recognition or cytokine signaling-CD69 is rapidly expressed on the surface of platelets, T lymphocytes, and NK cells, where it activates distinct signaling pathways across different cell types. CD69 negatively regulates Th17 cell differentiation through a carbohydrate-dependent interaction with galectin-1 (LGALS1) present on immature dendritic cells. It also acts via the S100A8/S100A9 complex on peripheral blood monocytes to promote the conversion of naive CD4+ T cells into regulatory T cells. Mechanistically, it specifically recognizes Pseudomonas aeruginosa, promoting ERK1 activation and the subsequent secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) and other inflammatory cytokines.
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Subcellular Localization
Cell membrane; Single-pass type II membrane protein
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Expression
Tissue_specificity:It is expressed on the surface of activated T cells, B cells, natural killer cells, neutrophils, eosinophils, epidermal Langerhans cells, and platelets.
Induction:By antigens, mitogens or activators of PKC on the surface of T and B-lymphocytes. By interaction of IL-2 with the p75 IL-2R on the surface of NK cells -
Subunit
Homodimer; disulfide-linked. Interacts with S100A8 and S100A9. Interacts with galactin-1/LGALS1. Interacts with S1PR1; this interaction mediates S1PR1 degradation
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SwissProt ID
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Synonyms
CD69; CLEC2C; Early activation antigen CD69; Activation inducer molecule; AIM; BL-AC/P26; C-type lectin domain family 2 member C; EA1; Early T-cell activation antigen p60; GP32/28; Leukocyte surface antigen Leu-23; MLR-3; CD antigen CD69; CD69 nanobody;
Documentation
[1]. de la Fuente H, et al. The leukocyte activation receptor CD69 controls T cell differentiation through its interaction with galectin-1. Mol Cell Biol. 2014 Jul;34(13):2479-87. [Content Brief]
[2]. Lin CR, et al. Glycosylation-dependent interaction between CD69 and S100A8/S100A9 complex is required for regulatory T-cell differentiation. FASEB J. 2015 Dec;29(12):5006-17. [Content Brief]
[3]. Jiménez-Fernández M, et al. CD69-oxLDL ligand engagement induces Programmed Cell Death 1 (PD-1) expression in human CD4 + T lymphocytes. Cell Mol Life Sci. 2022 Aug 5;79(8):468. [Content Brief]
[4]. Jiang Y, et al. CD69 mediates the protective role of adipose tissue-derived mesenchymal stem cells against Pseudomonas aeruginosa pulmonary infection. Clin Transl Med. 2021 Nov;11(11):e563. [Content Brief]
[5]. Chen H, et al. Transmembrane protein CD69 acts as an S1PR1 agonist. Elife. 2023 Apr 11;12:. [Content Brief]
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