1. Cell Cycle/DNA Damage
    Epigenetics
    Anti-infection
  2. HDAC
    HIV
  3. PTACH

PTACH (Synonyms: NCH-51)

Cat. No.: HY-12954 Purity: 99.65%
Handling Instructions

PTACH (NCH-51) is a potent HDAC inhibitor with IC50s of 48 nM, 32 nM, and 41 nM for HDAC1, HDAC4, and HDAC6, respectively. PTACH exerts potent growth inhibition against various cancer cells (EC50s of 1.1-9.1 µM) .

For research use only. We do not sell to patients.

PTACH Chemical Structure

PTACH Chemical Structure

CAS No. : 848354-66-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 88 In-stock
Estimated Time of Arrival: December 31
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg USD 450 Get quote
100 mg USD 650 Get quote
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Based on 1 publication(s) in Google Scholar

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Description

PTACH (NCH-51) is a potent HDAC inhibitor with IC50s of 48 nM, 32 nM, and 41 nM for HDAC1, HDAC4, and HDAC6, respectively. PTACH exerts potent growth inhibition against various cancer cells (EC50s of 1.1-9.1 µM) [1][2].

IC50 & Target[1][2]

HDAC1

48 nM (IC50)

HDAC4

32 nM (IC50)

HDAC6

41 nM (IC50)

HIV-1

 

In Vitro

PTACH (compound 51) treatment elevates the levels of acetylated histone H4 and p21WAF1/CIP1 in a dose-dependent manner[1].
In cancer cell growth inhibition assay, PTACH (compound 51) shows strong activity. PTACH inhibits various cancer cells with EC50 values of 2.3 μM, 9.1 μM, 3.0 μM, 2.6 μM, 1.1 μM, 4.5 μM, 2.4 μM, 5.0 μM, and 4.5 μM for MDA-MB-231, SNB-78, HCT116, NCI-H226, LOX-IMVI, SK-OV-3, RXF-631L, St-4, and DU-145 cells, respectively[1].
PTACH (NCH-51) augments the HIV-1 production in latently infected OM10.1 cells and such reactivation is associated with a loss of HDAC1 occupancy and subsequent hyperacetylation of histones in nuc-1 at the HIV-1 promoter[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HCT 116 cells
Concentration: 1 μM, 5 μM, 25 μM
Incubation Time: 8 hours
Result: Gave rise to elevated and dose-dependent levels of acetylated histone H4 and p21WAF1/CIP1.
Molecular Weight

390.56

Formula

C₂₀H₂₆N₂O₂S₂

CAS No.

848354-66-5

SMILES

CC(C)C(SCCCCCCC(NC1=NC(C2=CC=CC=C2)=CS1)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (128.02 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5604 mL 12.8021 mL 25.6043 mL
5 mM 0.5121 mL 2.5604 mL 5.1209 mL
10 mM 0.2560 mL 1.2802 mL 2.5604 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.40 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.40 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

PTACHNCH-51NCH51NCH 51HDACHIVHistone deacetylasesHuman immunodeficiency virusAnti-cancerp21WAF1/CIP1SAHAHIV-1hyperacetylationInhibitorinhibitorinhibit

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PTACH
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