2. PROTAC Epigenetics
  3. PROTACs Histone Methyltransferase
  4. PROTAC EZH2 Degrader-17

PROTAC EZH2 Degrader-17 (compound 52) is a PROTAC protein degrader targeting EZH2 with an antiproliferative IC50 of 18.32 μM in lymphoma cells. PROTAC EZH2 Degrader-17 exhibits antiproliferative activity against lymphoma cells. PROTAC EZH2 Degrader-17 can be used for the research of lymphoma.
(Pink: EZH2 ligand (HY-147230); Blue: Cereblon ligand (HY-14658); Black: linker).

For research use only. We do not sell to patients.

PROTAC EZH2 Degrader-17

PROTAC EZH2 Degrader-17 Chemical Structure

CAS No. : 3093642-23-7

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PROTAC EZH2 Degrader-17 Related Antibodies

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 NSD3/WHSC1L1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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Description

PROTAC EZH2 Degrader-17 (compound 52) is a PROTAC protein degrader targeting EZH2 with an antiproliferative IC50 of 18.32 μM in lymphoma cells. PROTAC EZH2 Degrader-17 exhibits antiproliferative activity against lymphoma cells. PROTAC EZH2 Degrader-17 can be used for the research of lymphoma[1]. (Pink: EZH2 ligand (HY-147230); Blue: Cereblon ligand (HY-14658); Black: linker).

In Vitro

PROTAC EZH2 Degrader-17 induces antiproliferative effects in SU-DHL-6 and HBL-1 diffuse large B-cell lymphoma cell lines with IC50 values of >30.00 μM and 18.32 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC EZH2 Degrader-17 Related Antibodies
Molecular Weight

1186.36

Formula

C62H79N11O13
CAS No.
SMILES

O=C(C1=CC(C2=CC=C(CN3CCN(CC3)C(C4=CN(CCOCCOCCOCCOCCOCCNC5=CC=CC(C(N6C7C(NC(CC7)=O)=O)=O)=C5C6=O)N=N4)=O)C=C2)=CC(N(C8CCOCC8)CC)=C1C)NCC9=C(C)C=C(C)NC9=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC EZH2 Degrader-17 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC EZH2 Degrader-173093642-23-7PROTACsHistone MethyltransferaseHBL-1lymphoma cellsEZH2CRBNSU-DHL-6diffuse large B-cell lymphoma cell linesInhibitorinhibitorinhibit

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