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Cat. No.: HY-181300

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PROTAC EZH2 Degrader-17

PROTAC EZH2 Degrader-17 (compound 52) is a PROTAC protein degrader targeting EZH2 with an antiproliferative IC₅₀ of 18.32 μM in lymphoma cells. PROTAC EZH2 Degrader-17 exhibits antiproliferative activity against lymphoma cells. PROTAC EZH2 Degrader-17 can be used for the research of lymphoma.
(Pink: EZH2 ligand (HY-147230); Blue: Cereblon ligand (HY-14658); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 3093642-23-7
Formula: C₆₂H₇₉N₁₁O₁₃
Molecular Weight:1186.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC EZH2 Degrader-17 Chemical Structure

CAS No.: 3093642-23-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Help & FAQs
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Biological Activity

Description

PROTAC EZH2 Degrader-17 (compound 52) is a PROTAC protein degrader targeting EZH2 with an antiproliferative IC₅₀ of 18.32 μM in lymphoma cells. PROTAC EZH2 Degrader-17 exhibits antiproliferative activity against lymphoma cells. PROTAC EZH2 Degrader-17 can be used for the research of lymphoma^[1]. (Pink: EZH2 ligand (HY-147230); Blue: Cereblon ligand (HY-14658); Black: linker).

All PROTACs Isoforms :

All Histone Methyltransferase Isoforms :

In Vitro

PROTAC EZH2 Degrader-17 induces antiproliferative effects in SU-DHL-6 and HBL-1 diffuse large B-cell lymphoma cell lines with IC₅₀ values of >30.00 μM and 18.32 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3093642-23-7
Molecular Weight 1186.36
Formula C₆₂H₇₉N₁₁O₁₃
SMILES

O=C(C1=CC(C2=CC=C(CN3CCN(CC3)C(C4=CN(CCOCCOCCOCCOCCOCCNC5=CC=CC(C(N6C7C(NC(CC7)=O)=O)=O)=C5C6=O)N=N4)=O)C=C2)=CC(N(C8CCOCC8)CC)=C1C)NCC9=C(C)C=C(C)NC9=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. S Abulkhair H, et al. Therapeutic horizons in the development of PROTAC-based EZH2 inhibitors: recent achievements, comparative analysis, and future perspectives. RSC Adv. 2026;16(4):3034-3056. Published 2026 Jan 14. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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PROTAC EZH2 Degrader-17

All PROTACs Isoforms

All Histone Methyltransferase Isoforms