Splenopentin diacetate

Name: Splenopentin diacetate
Brand: MedChemExpress
SKU: HY-P0085
Rating: 4.5 (1 reviews)

Cat. No.: HY-P0085 Purity: 98.89%: Data Sheet
COA

SDS
Handling Instructions
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Splenopentin diacetate is a synthetic immunomodulating pentapeptide corresponding to the residues 32-36 of the splenic hormone splenin. Splenopentin diacetate influences both early T and B cell differentiation, to increase the number of antibody-forming cells in mice after gamma irradiation.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Splenopentin diacetate Chemical Structure

CAS No. : 105184-37-0

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	Get quote
10 mg	Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Splenopentin (1-100 μM) augments human NK cells and has no cytotoxicity^[2].
Splenopentin (0.1 ng/mL-10 μg/mL; 3 h) induces phenotypic differentiation of both T- and B-cell precursor cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Splenopentin (1 mg/kg; i.p. three times a week for 7-90 d) accelerates Langerhans cell recruitment and leads to pretreatment levels of Langerhans cell (LC) density in the skin of mice^[4].
Splenopentin (0.01-100 μg per mouse; i.p.) has no demonstrable effect on neuromuscular transmission of mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female Balb/c/Bln mice were injected Cyclophosphamide or Dexamethasone for 5 consecutive days^[4]
Dosage:	1 mg/kg
Administration:	I.p. three times a week for 7-90 days
Result:	Reached the normal number of epidermal LCs at 28 days after the beginning of Cyclophosphamide treatment. Accelerated restoration process and reached the normal LC density in the skin after 70 days in Dexamethasone treatment grops.

Molecular Weight

813.90

Formula

C₃₅H₅₉N₉O₁₃

CAS No.

105184-37-0

Appearance

Solid

Color

White to off-white

Sequence

Arg-Lys-Glu-Val-Tyr

Sequence Shortening

RKEVY

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (122.87 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2287 mL	6.1433 mL	12.2865 mL
5 mM	0.2457 mL	1.2287 mL	2.4573 mL
10 mM	0.1229 mL	0.6143 mL	1.2287 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.89%

Select Batch:

Data Sheet (274 KB) SDS (254 KB)

COA (249 KB) LCMS (95 KB) Elemental Analysis Report (108 KB)

Handling Instructions (2659 KB)

References

[1]. Singh VK, et, al. Thymopentin and splenopentin as immunomodulators. Current status. Immunol Res. 1998;17(3):345-68. [Content Brief]

[2]. Rastogi A, et, al. Augmentation of human natural killer cells by splenopentin analogs. FEBS Lett. 1993 Feb 8;317(1-2):93-5. [Content Brief]

[3]. Audhya T, et, al. Contrasting biological activities of thymopoietin and splenin, two closely related polypeptide products of thymus and spleen. Proc Natl Acad Sci U S A. 1984 May;81(9):2847-9. [Content Brief]

[4]. Gruner S, et, al. Stimulation of the recruitment of epidermal Langerhans cells by splenopentin. Arch Dermatol Res. 1990;281(8):526-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.2287 mL	6.1433 mL	12.2865 mL	30.7163 mL
	5 mM	0.2457 mL	1.2287 mL	2.4573 mL	6.1433 mL
	10 mM	0.1229 mL	0.6143 mL	1.2287 mL	3.0716 mL
	15 mM	0.0819 mL	0.4096 mL	0.8191 mL	2.0478 mL
	20 mM	0.0614 mL	0.3072 mL	0.6143 mL	1.5358 mL
	25 mM	0.0491 mL	0.2457 mL	0.4915 mL	1.2287 mL
	30 mM	0.0410 mL	0.2048 mL	0.4096 mL	1.0239 mL
	40 mM	0.0307 mL	0.1536 mL	0.3072 mL	0.7679 mL
	50 mM	0.0246 mL	0.1229 mL	0.2457 mL	0.6143 mL
	60 mM	0.0205 mL	0.1024 mL	0.2048 mL	0.5119 mL
	80 mM	0.0154 mL	0.0768 mL	0.1536 mL	0.3840 mL
	100 mM	0.0123 mL	0.0614 mL	0.1229 mL	0.3072 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.