Splenopentin diacetate
Based on 1 Customer Validation
Splenopentin diacetate is a synthetic immunomodulating pentapeptide corresponding to the residues 32-36 of the splenic hormone splenin. Splenopentin diacetate influences both early T and B cell differentiation, to increase the number of antibody-forming cells in mice after gamma irradiation.
For research use only. We do not sell to patients.
- Purity: 98.89%
- CAS No.: 105184-37-0
- Formula: C35H59N9O13
- Molecular Weight:813.90
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Splenopentin (1-100 μM) augments human NK cells and has no cytotoxicity[2].
Splenopentin (0.1 ng/mL-10 μg/mL; 3 h) induces phenotypic differentiation of both T- and B-cell precursor cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Splenopentin (0.01-100 μg per mouse; i.p.) has no demonstrable effect on neuromuscular transmission of mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female Balb/c/Bln mice were injected Cyclophosphamide or Dexamethasone for 5 consecutive days[4]
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Dosage:1 mg/kg
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Administration:I.p. three times a week for 7-90 days
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Result:Reached the normal number of epidermal LCs at 28 days after the beginning of Cyclophosphamide treatment.
Accelerated restoration process and reached the normal LC density in the skin after 70 days in Dexamethasone treatment grops.
Chemical Information
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CAS No. 105184-37-0
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Appearance Solid
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Molecular Weight 813.90
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Formula C35H59N9O13
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Color White to off-white
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Sequence
Arg-Lys-Glu-Val-Tyr
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Sequence Shortening
RKEVY
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : ≥ 100 mg/mL (122.87 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Singh VK, et, al. Thymopentin and splenopentin as immunomodulators. Current status. Immunol Res. 1998;17(3):345-68. [Content Brief]
[2]. Rastogi A, et, al. Augmentation of human natural killer cells by splenopentin analogs. FEBS Lett. 1993 Feb 8;317(1-2):93-5. [Content Brief]
[3]. Audhya T, et, al. Contrasting biological activities of thymopoietin and splenin, two closely related polypeptide products of thymus and spleen. Proc Natl Acad Sci U S A. 1984 May;81(9):2847-9. [Content Brief]
[4]. Gruner S, et, al. Stimulation of the recruitment of epidermal Langerhans cells by splenopentin. Arch Dermatol Res. 1990;281(8):526-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.2287 mL | 6.1433 mL | 12.2865 mL | 30.7163 mL |
| 5 mM | 0.2457 mL | 1.2287 mL | 2.4573 mL | 6.1433 mL | |
| 10 mM | 0.1229 mL | 0.6143 mL | 1.2287 mL | 3.0716 mL | |
| 15 mM | 0.0819 mL | 0.4096 mL | 0.8191 mL | 2.0478 mL | |
| 20 mM | 0.0614 mL | 0.3072 mL | 0.6143 mL | 1.5358 mL | |
| 25 mM | 0.0491 mL | 0.2457 mL | 0.4915 mL | 1.2287 mL | |
| 30 mM | 0.0410 mL | 0.2048 mL | 0.4096 mL | 1.0239 mL | |
| 40 mM | 0.0307 mL | 0.1536 mL | 0.3072 mL | 0.7679 mL | |
| 50 mM | 0.0246 mL | 0.1229 mL | 0.2457 mL | 0.6143 mL | |
| 60 mM | 0.0205 mL | 0.1024 mL | 0.2048 mL | 0.5119 mL | |
| 80 mM | 0.0154 mL | 0.0768 mL | 0.1536 mL | 0.3840 mL | |
| 100 mM | 0.0123 mL | 0.0614 mL | 0.1229 mL | 0.3072 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Splenopentin diacetate Related Classifications
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