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Splenopentin diacetate 

Cat. No.: HY-P0085
Handling Instructions

Splenopentin diacetate is a synthetic immunomodulating pentapeptide corresponding to the residues 32-36 of the splenic hormone splenin. Splenopentin diacetate influences both early T and B cell differentiation, to increase the number of antibody-forming cells in mice after gamma irradiation.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Splenopentin diacetate Chemical Structure

Splenopentin diacetate Chemical Structure

CAS No. : 105184-37-0

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Description

Splenopentin diacetate is a synthetic immunomodulating pentapeptide corresponding to the residues 32-36 of the splenic hormone splenin. Splenopentin diacetate influences both early T and B cell differentiation, to increase the number of antibody-forming cells in mice after gamma irradiation[1][2].

In Vitro

Splenopentin (1-100 μM) augments human NK cells and has no cytotoxicity[2].
Splenopentin (0.1 ng/mL-10 μg/mL; 3 h) induces phenotypic differentiation of both T- and B-cell precursor cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Splenopentin (1 mg/kg; i.p. three times a week for 7-90 d) accelerates Langerhans cell recruitment and leads to pretreatment levels of Langerhans cell (LC) density in the skin of mice[4].
Splenopentin (0.01-100 μg per mouse; i.p.) has no demonstrable effect on neuromuscular transmission of mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Balb/c/Bln mice were injected Cyclophosphamide or Dexamethasone for 5 consecutive days[4]
Dosage: 1 mg/kg
Administration: I.p. three times a week for 7-90 days
Result: Reached the normal number of epidermal LCs at 28 days after the beginning of Cyclophosphamide treatment.
Accelerated restoration process and reached the normal LC density in the skin after 70 days in Dexamethasone treatment grops.
Molecular Weight

813.90

Formula

C₃₅H₅₉N₉O₁₃

CAS No.

105184-37-0

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
References
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Splenopentin diacetateOtherssyntheticimmunomodulatingpentapeptidesplenichormonespleninTBdifferentiationantibodyInhibitorinhibitorinhibit

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Splenopentin diacetate
Cat. No.:
HY-P0085
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