1. Metabolic Enzyme/Protease
    Cell Cycle/DNA Damage
  2. Dihydroorotate Dehydrogenase
    DNA/RNA Synthesis
  3. DHODH-IN-3

DHODH-IN-3 

Cat. No.: HY-135618
Handling Instructions

DHODH-IN-3 (compound 3) is a potent inhibitor of Human Dihydroorotate Dehydrogenases (HsDHODH) with an IC50 value of 261 nM. DHODH-IN-3 binds to the the ubiquinone binding cavities in DHODH with a Kiapp of 32 nM. DHODH-IN-3 has the potential for malaria treatment.

For research use only. We do not sell to patients.

DHODH-IN-3 Chemical Structure

DHODH-IN-3 Chemical Structure

CAS No. : 1148126-04-8

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Description

DHODH-IN-3 (compound 3) is a potent inhibitor of Human Dihydroorotate Dehydrogenases (HsDHODH) with an IC50 value of 261 nM. DHODH-IN-3 binds to the the ubiquinone binding cavities in DHODH with a Kiapp of 32 nM. DHODH-IN-3 has the potential for malaria treatment[1].

IC50 & Target

IC50: 261 nM (HsDHODH)[1]

In Vitro

DHODH-IN-3 (compound 3) show good inhibitory effects on HsDHODH with IC50 value of 261 nM. It binds to HsDHODH with a Kiapp value of 32 nM[1].

Molecular Weight

312.75

Formula

C₁₇H₁₃ClN₂O₂

CAS No.

1148126-04-8

SMILES

C/C(O)=C(C#N)/C(NC1=CC=C(C2=CC=CC=C2)C=C1Cl)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DHODH-IN-3Dihydroorotate DehydrogenaseDNA/RNA SynthesisDHODHmalariaHsDHODHInhibitorinhibitorinhibit

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DHODH-IN-3
Cat. No.:
HY-135618
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