1148126-04-8
1148126-04-8
Chemical Structure
DHODH-IN-3
- CAS No.: 1148126-04-8
- Formula:C17H13ClN2O2
- Molecular Weight:312.75
IUPAC Name: (Z)-N-(3-chloro-[1,1'-biphenyl]-4-yl)-2-cyano-3-hydroxybut-2-enamide
InChIKey: OVZOHAXVUVNPQF-KAMYIIQDSA-N
SMILES: C/C(O)=C(C#N)/C(NC1=CC=C(C2=CC=CC=C2)C=C1Cl)=O
Biological Activity: DHODH-IN-3 (compound 3) is a potent inhibitor of Human Dihydroorotate Dehydrogenases (HsDHODH) with an IC50 value of 261 nM. DHODH-IN-3 binds to the the ubiquinone binding cavities in DHODH with a Kiapp of 32 nM. DHODH-IN-3 has the potential for malaria treatment[1].
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DHODH-IN-3 | DHODH-IN-3 (compound 3) is a potent inhibitor of Human Dihydroorotate Dehydrogenases (HsDHODH) with an IC50 value of 261 nM. DHODH-IN-3 binds to the the ubiquinone binding cavities in DHODH with a Kiapp of 32 nM. DHODH-IN-3 has the potential for malaria treatment. | |||||||||||||||||||||
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References
Keywords
