1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. PD173212

PD173212 

Cat. No.: HY-103318
Handling Instructions

PD173212 is a selective N-type voltage sensitive calcium channel (VSCC) blocker, with an IC50 of 36 nM in IMR-32 assays.

For research use only. We do not sell to patients.

PD173212 Chemical Structure

PD173212 Chemical Structure

CAS No. : 217171-01-2

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 285 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 285 In-stock
Estimated Time of Arrival: December 31
Solid
2 mg USD 120 In-stock
Estimated Time of Arrival: December 31
5 mg USD 216 In-stock
Estimated Time of Arrival: December 31
10 mg USD 318 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE PD173212

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PD173212 is a selective N-type voltage sensitive calcium channel (VSCC) blocker, with an IC50 of 36 nM in IMR-32 assays.

IC50 & Target

IC50: 36 nM (VSCC)[1]

In Vitro

PD173212 (PD 173212, 300 nM) potently blocks recombinant B-class (N-type) calcium channel currents 78±7.8%, with an IC50 of 74 nM, by whole-cell voltage-clamp techniques. PD 173212 possesses selectivity for non L-type Ca2+ channels versus neuronal Na+, K+, and L-type Ca2+ channels[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PD173212 (30 mg/kg, i.v.) shows moderate efficacy in preventing tonic seizures in the audiogenic seizure model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

599.85

Formula

C38H53N3O3

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (166.71 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6671 mL 8.3354 mL 16.6708 mL
5 mM 0.3334 mL 1.6671 mL 3.3342 mL
10 mM 0.1667 mL 0.8335 mL 1.6671 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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PD173212
Cat. No.:
HY-103318
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