TRIM32 Antibody (YA6813)

TRIM32 Antibody (YA6813) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TRIM32.

Predicted band size: 72 kDa;

Q13049

22954 [NCBI]

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Function：E3 ubiquitin ligase that plays a role in various biological processes including neural stem cell differentiation, innate immunity, inflammatory resonse and autophagy (PubMed:19349376, PubMed:31123703). Plays a role in virus-triggered induction of IFN-beta and TNF-alpha by mediating the ubiquitination of STING1. Mechanistically, targets STING1 for 'Lys-63'-linked ubiquitination which promotes the interaction of STING1 with TBK1 (PubMed:22745133). Regulates bacterial clearance and promotes autophagy in Mycobacterium tuberculosis-infected macrophages (PubMed:37543647). Negatively regulates TLR3/4-mediated innate immune and inflammatory response by triggering the autophagic degradation of TICAM1 in an E3 activity-independent manner (PubMed:28898289). Plays an essential role in oxidative stress induced cell death by inducing loss of transmembrane potential and enhancing mitochondrial reactive oxygen species (ROS) production during oxidative stress conditions (PubMed:32918979). Ubiquitinates XIAP and targets it for proteasomal degradation (PubMed:21628460). Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation (PubMed:19349376). May ubiquitinate BBS2 (PubMed:22500027). Ubiquitinates PIAS4/PIASY and promotes its degradation in keratinocytes treated with UVB and TNF-alpha (By similarity). Also acts as a regulator of autophagy by mediating formation of unanchored 'Lys-63'-linked polyubiquitin chains that activate ULK1: interaction with AMBRA1 is required for ULK1 activation (PubMed:31123703). Positively regulates dendritic branching by promoting ubiquitination and subsequent degradation of the epigenetic factor CDYL (PubMed:34888944). Under metabolic stress and phosphorylation by CHK2, mediates 'Lys-63'-linked ubiquitination of ATG7 at 'Lys-45' to initiate autophagy (PubMed:37943659)|(Microbial infection) May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo (PubMed:7778269). Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo (PubMed:7778269)

Subcellular Localization：Cytoplasm,Mitochondrion,Endoplasmic reticulum

Expression：
Tissue_Specificity: Spleen, thymus, prostate, testis, ovary, intestine, colon and skeletal muscle

Subunit：It self-associates (PubMed:19349376)

72 kda Tat interacting Protein antibody; 72 kDa Tat-interacting protein antibody; BBS11 antibody; E3 ubiquitin-protein ligase TRIM32 antibody; HT2A antibody; LGMD2H antibody; Limb girdle muscular dystrophy 2H (autosomal recessive) antibody; Limb girdle muscular dystrophy 2H antibody; Muscular dystrophy Hutterite type antibody; TAT interactive protein 72KD antibody; 72 kda Tat interacting Protein antibody; 72 kDa Tat-interacting protein antibody; BBS11 antibody; E3 ubiquitin-protein ligase TRIM32 antibody; HT2A antibody; LGMD2H antibody; Limb girdle muscular dystrophy 2H (autosomal recessive) antibody; Limb girdle muscular dystrophy 2H antibody; Muscular dystrophy Hutterite type antibody; TAT interactive protein 72KD antibody; TAT; IP : antibody; TRI32_HUMAN antibody; Trim32 antibody; Tripartite Motif Containing Protein 32 antibody; Tripartite motif-containing protein 32 antibody; Zinc finger protein HT2A antibody;